The Lab

Our mission is to develop and translate innovative technologies through biomaterials design at the interface of nanoscience, engineering, biology, and medicine to address the unmet critical needs in healthcare.

Our lab specializes in engineering nanomaterials for delivery of nucleic acid and protein therapeutics, soft tissue regeneration, and immunoengineering. Specifically, we aim to understand the structure-property-function relationship of biomaterials and technology platforms to enhance their therapeutic efficacy and develop new methods for scalable manufacturing and translation.


Funded Projects

We build upon the strong collaborative projects with top scientists and clinicians at Hopkins and beyond. We are part of the Institute for NanoBioTechnology (INBT) and Department of Materials Science and Engineering located on the engineering campus, and the Translational Tissue Engineering Center (TTEC) and Department of Biomedical Engineering located on the medical campus. Our research has a strong translational focus and enjoys strong collaborations with industry partners.

Selected Recent Publications

Li L’, Yao ZC’, et al., A nanofiber-hydrogel composite improves tissue repair in a rat model of Crohn’s disease perianal fistulas. Sci. Adv. 2023 Jan 4;9(1):eade1067. PMID: 36598982.

Li S’, Hu Y’, et al., Payload distribution and capacity of mRNA lipid nanoparticles. Nat Commun. 2022 Sep 23; 13(1): 5561. PMID: 36151112.

Li L’, Zhang Y’, et al., Quaternary nanoparticles enable sustained release of bortezomib for hepatocellular carcinoma. Hepatology. 2022 May 21. PMID: 35596926. [Cover]

Hu Y’, Zhu Y’, et al., Size-Controlled and Shelf-Stable DNA Particles for Production of Lentiviral Vectors. Nano Lett. 21(13): 5697-5705 (2021). PMID: 34228937.

Hu Y, et al., Kinetic control in assembly of plasmid DNA/polycation complex nanoparticles. ACS Nano. 13 (9): 10161–10178 (2019). PMID: 31503450.

Li X, Cho B, et al., Nanofiber-hydrogel composite-mediated angiogenesis for soft tissue reconstruction. Sci. Transl. Med. 2019; 11(490). pii: eaau6210. PMID: 31043572.

Hickey JW, et al., Engineering an artificial T-cell stimulating matrix for immunotherapy. Adv. Mater. 2019 Apr 10: e1807359. PMID: 30968468 [Cover].

Join our team!