1. Zhu Y, Ma J, Shen R, Lin J, Li S, Lu X, Stelzel JL, Kong J, Cheng L, Vuong I, Yao ZC, Wei C, Korinetz NM, Toh WH, Choy J, Reynolds RA, Shears MJ, Cho WJ, Livingston NK, Howard GP, Hu Y, Tzeng SY, Zack DJ, Green JJ, Zheng L, Doloff JC, Schneck JP, Reddy SK, Murphy SC, Mao HQ. Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity. Nat Biomed Eng. 2023 Dec 11. doi: 10.1038/s41551-023-01131-0. PMID: 38082180.
  2. Chen L, Song X, Yao Z, Zhou C, Yang J, Yang Q, Zhou C, Yang J, Yang Q, Chen J, Wu J, Sun Z, Gu L, Ma Y, Lee SJ, Zhang C, Mao HQ, Sun L. Gelatin nanofiber-reinforced decellularized amniotic membrane promotes axon regeneration and functional recovery in the surgical treatment of peripheral nerve injury. Biomaterials. 2023 Sep 1; 300:122207. doi: 10.1016/j.biomaterials.2023.122207. PMID: 37352606.
  3. Sarhane KA, Qiu C, Harris TGW, Hanwright PJ, Mao HQ, Tuffaha SH. Translational bioengineering strategies for peripheral nerve regeneration: opportunities, challenges, and novel concepts. Neural Regen Res. 2023 Jun 23; 18(6):1129. doi: 10.4103/1673-5374.358616. PMID: 36453398; PMCID: PMC9838159.
  4. Harris T, Padovano W, Qiu C, Suresh V, Perkins P, Poisler M, Lee NAE, Sarhane K, Hanwright P, Segna K, Hoke A, Mao HQ, Tuffaha S. 60. Insulin Like Growth Factor 1 Nanoparticle Based Drug Delivery System for Peripheral Nerve Injury in Non-human Primates. Plast Reconstr Surg – Glob Open. 2023 May 19; 11(5S):37. doi: 10.1097/01.GOX.0000937832.46760.88. PMCID: PMC10194612.
  5. Bhoopalam M, Kong J, Yang K, Mao HQ, Reddy SK. 7. A Mechanically Tunable Protein Nanofiber-hydrogel Composite for Soft Tissue Restoration. Plast Reconstr Surg Glob Open. 2023 May 19; 11(5 Suppl):5. doi: 10.1097/01.GOX.0000937624.16654.ed. PMCID: PMC10194486.
  6. Lee E, Qiu C, Harris T, Suresh V, Padovano W, Sulaiman HO, Suresh R, Lee A, Guionneau NV, Aslami Z, Zhang Y, Yao Z, Hoke A, Mao HQ, Tuffaha S. 15. Sustained Agrin Nanoparticle Delivery Improves Neuromuscular Junction Reinnervation and Functional Recovery after Chronic Denervation. Plast Reconstr Surg – Glob Open. 2023 May 19; 11(5S):10. doi: 10.1097/01.GOX.0000937656.08175.2c. PMCID: PMC10194582.
  7. Bhoopalam M, Qiu C, Harris TGW, Tuffaha S, Mao HQ, Reddy SK. 14. A Tunable Nanoparticle-based Botulinum Toxin Formulation for Extended Duration of Therapeutic Effect. Plast Reconstr Surg – Glob Open. 2023 May 19; 11(5S):9. doi: 10.1097/01.GOX.0000937652.43692.e5. PMCID: PMC10194554.
  8. Lee E, Qiu C, Harris T, Suresh V, Padovano W, Sulaiman HO, Suresh R, Lee A, Guionneau NV, Aslami Z, Zhang Y, Yao Z, Hoke A, Mao HQ, Tuffaha S. D20. Agrin Nanoparticles in a Nanofiber Hydrogel-based Drug Delivery System Improve Neuromuscular Junction Reinnervation following Chronic Denervation. Plast Reconstr Surg Glob Open. 2023 Apr 26; 11(4 Suppl):71–2. doi: 10.1097/01.GOX.0000934692.22671.df. PMCID: PMC10125567.
  9. Li L, Zhou Y, Zhang Y, Hu H, Mao HQ, Selaru FM. A combination therapy of bortezomib, CXCR4 inhibitor, and checkpoint inhibitor is effective in cholangiocarcinoma in vivo. iScience. 2023 Mar 17; 26(3):106095. doi: 10.1016/j.isci.2023.106095. PMID: 36843847; PMCID: PMC9950944.
  10. Li W, Berlinicke C, Huang Y, Giera S, McGrath AG, Fang W, Chen C, Takaesu F, Chang X, Duan Y, Kumar D, Chang C, Mao HQ, Sheng G, Dodge JC, Ji H, Madden S, Zack DJ, Chamling X. High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells. iScience. 2023 Mar 17; 26(3):106156. doi: 10.1016/j.isci.2023.106156. PMID: 36852281; PMCID: PMC9958491.
  11. Parian AM, Li L, Duraes LC, Cheng J, Hu H, Yao Z, Donet J, Salem G, Iuga A, Salimian K, Izzi J, Zaheer A, Mao HQ, Gearhart S, Selaru FM. A Novel Patient-like Swine Model of Perianal Crohn’s Disease. Dis Colon Rectum. 2023 Jan 9; 66(3):425–33. doi: 10.1097/DCR.0000000000002369. PMID: 35499985.
  12. Li L, Yao ZC, Parian A, Yang YH, Chao J, Yin J, Salimian KJ, Reddy Sk, Zaheer A, Gearhart SL, Mao HQ, Selaru FM. A nanofiber-hydrogel composite improves tissue repair in a rat model of Crohn’s disease perianal fistulas. Sci Adv. 2023 Jan 4; 9(1):eade1067. doi: 10.1126/sciadv.ade1067. PMID: 36598982; PMCID: PMC9812382.


  1. Somers SM, Gilbert-Honick J, Choi IY, K. W. Lo E, Lim H, Dias S, Wagner KR, Mao HQ, Cahan P, Lee G, Grayson WL. Engineering Skeletal Muscle Grafts with PAX7::GFP-Sorted Human Pluripotent Stem Cell-Derived Myogenic Progenitors on Fibrin Microfiber Bundles for Tissue Regeneration. Bioengineering. 2022 Nov 15; 9(11):693. doi: 10.3390/bioengineering9110693. PMID: 36421094; PMCID: PMC9687588.
  2. Livingston N, Hickey J, Sim H, Mao HQ, Schneck J. 256 In vivo expansion of endogenous antigen-specific CD8+ T cells using artificial T-cell stimulating microparticles. JITC. 2022 Nov 07; 10(Suppl 2):A1–A1595. doi: 10.1136/jitc-2022-SITC2022.0256.
  3. Lee E, Qiu C, Harris T, von Guionneau N, Omer Sulaiman H, Suresh R, Lee A, Zhang Y, Kusamanov M, Aslami Z, Generoso M, Hoke A, Mao HQ, Tuffaha S. Sustained Agrin Nanoparticle Delivery Ameliorates Effects of Denervation and Preserves Neuromuscular Junction Morphology after Peripheral Nerve Injury. Plast Reconstr Surg Glob Open. 2022 Oct 24; 10(10 Suppl):123. doi: 10.1097/01.GOX.0000898968.94111.b3. PMCID: PMC9592508.
  4. Elliott MB, Matsushita H, Shen J, Yi J, Inoue T, Brady T, Santhanam L, Mao HQ, Hibino N, Gerecht S. Off-the-shelf, heparinized small diameter vascular graft limits acute thrombogenicity in a porcine model. Acta Biomater. 2022 Oct 1; 151:134–47. doi: 10.1016/j.actbio.2022.07.061. PMID: 35933100
  5. Li S, Hu Y, Li A, Lin J, Hsieh K, Schneiderman Z, Zhang P, Zhu Y, Qiu C, Kokkoli E, Wang TH, Mao HQ. Payload distribution and capacity of mRNA lipid nanoparticles. Nat Commun. 2022 Sep 23;13(1):5561. doi: 10.1038/s41467-022-33157-4. PMID: 36151112; PMCID: PMC9508184.
  6. Yao ZC, Yang YH, Kong J, Zhu Y, Li L, Chang C, Zhang C, Yin J, Chao J, Selaru FM, Reddy SK, Mao HQ. Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling. Small. 2022 Aug 10: e2202309. doi: 10.1002/smll.202202309. PMID: 35948487.
  7. Elliott MB, Matsushita H, Shen J, Yi J, Inoue T, Brady T, Santhanam L, Mao HQ, Hibino N, Gerecht S. Off-the-shelf, heparinized small diameter vascular graft limits acute thrombogenicity in a porcine model. Acta Biomater. 2022 Aug 4: S1742-7061(22)00463-9. doi: 10.1016/j.actbio.2022.07.061. PMID: 35933100.
  8. Zhu Y, Shen R, Vuong I, Reynolds RA, Shears MJ, Yao ZC, Hu Y, Cho WJ, Kong J, Reddy SK, Murphy SC, Mao HQ. Multi-step screening of DNA/lipid nanoparticles and co-delivery with siRNA to enhance and prolong gene expression. Nat Commun. 2022 Jul 25; 13(1): 4282. doi: 10.1038/s41467-022-31993-y. PMID: 35879315; PMCID: PMC9310361.
  9. Li L, Zhang Y, Zhou Y, Hu H, Hu Y, Georgiades C, Mao HQ, Selaru FM. Quaternary nanoparticles enable sustained release of bortezomib for hepatocellular carcinoma. Hepatology. 2022 May 21. doi: 10.1002/hep.32584. PMID: 35596926.
  10. Parian AM, Li L, Duraes LC, Cheng J, Hu H, Yao Z, Donet J, Salem G, Iuga A, Salimian K, Izzi J, Zaheer A, Mao HQ, Gearhart S, Selaru FM. A Novel Patient-like Swine Model of Perianal Crohn’s Disease. Dis Colon Rectum. 2022 Apr 25. doi: 10.1097/DCR.0000000000002369. PMID: 35499985.
  11. Haggerty AE, Maldonado-Lasunción I, Nitobe Y, Yamane K, Marlow MM, You H, Zhang C, Cho B, Li X, Reddy S, Mao HQ, Oudega M. The Effects of the Combination of Mesenchymal Stromal Cells and Nanofiber-Hydrogel Composite on Repair of the Contused Spinal Cord. Cells. 2022 Mar 28; 11(7): 1137. doi: 10.3390/cells11071137. PMID: 35406701; PMCID: PMC8997442.
  12. Henn D, Fischer KS, Chen K, Greco AH, Martin RA, Sivaraj D, Trotsyuk AA, Mao HQ, Reddy SK, Kneser U, Gurtner GC, Schmidt VJ, Sacks JM. Enrichment of Nanofiber Hydrogel Composite with Fractionated Fat Promotes Regenerative Macrophage Polarization and Vascularization for Soft-Tissue Engineering. Plast Reconstr Surg. 2022 Mar 1; 149(3): 433e-444e. doi: 10.1097/PRS.0000000000008872. PMID: 35196680.


  1. Hanwright PJ, Qiu C, Rath J, Zhou Y, von Guionneau N, Sarhane KA, Harris TGW, Howard GP, Malapati H, Lan MJ, Reddy S, Hoke A, Mao HQ, Tuffaha SH. Sustained IGF-1 delivery ameliorates effects of chronic denervation and improves functional recovery after peripheral nerve injury and repair. Biomaterials. 280: 121244. doi: 10.1016/j.biomaterials.2021.121244 (2021). PMID: 34794826.
  2. Howard GP, Bender NG, Khare P, López-Gutiérrez B, Nyasembe V, Weiss WJ, Simecka JW, Hamerly T, Mao HQ, Dinglasan RR. Immunopotentiation by lymph-node targeting of a malaria transmission-blocking nanovaccine. Front. Immunol. 12: 729086 (2021). doi: 10.3389/fimmu.2021.729086. PMID: 34512663.
  3. Slavin BR, Sarhane KA, von Guionneau N, Hanwright PJ, Qiu C, Mao HQ, Höke A, Tuffaha SH. Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury. Front Bioeng. Biotechnol. 9: 695850 (2021). doi: 10.3389/fbioe.2021.695850. PMID: 34249891.
  4. Hu Y, Zhu Y, Sutherland ND, Wilson DR, Pang M, Liu E, Staub JR, Berlinicke CA, Zack DJ, Green JJ, Reddy SK, Mao HQ. Size-Controlled and Shelf-Stable DNA Particles for Production of Lentiviral Vectors. Nano Lett. 21(13): 5697-5705 (2021). doi: 10.1021/acs.nanolett.1c01421. PMID: 34228937.
  5. Liu HW, Hu Y, Ren Y, Nam H, Santos JL, Ng S, Gong L, Brummet M, Carrington CA, Ullman CG, Pomper MG, Minn I, Mao HQ. Scalable Purification of Plasmid DNA Nanoparticles by Tangential Flow Filtration for Systemic Delivery. ACS Appl Mater Interfaces. 13(26): 30326-30336 (2021). doi: 10.1021/acsami.1c05750. PMID: 34162211.
  6. Hou J, Yang R, Vuong I, Li F, Kong J, Mao HQ. Biomaterials strategies to balance inflammation and tenogenesis for tendon repair. Acta Biomater. 130: 1-16 (2021). doi: 10.1016/j.actbio.2021.05.043. PMID: 34082095.
  7. Ahn HH, Carrington C, Hu Y, Liu HW, Ng C, Nam H, Park A, Stace C, West W, Mao HQ, Pomper MG, Ullman CG, Minn I. Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers. Sci Rep. 11(1): 9733 (2021). doi: 10.1038/s41598-021-89124-4. PMID: 33958660. 
  8. Chen L, Wang Y, Sun L, Yan J, Mao HQ. Nanomedicine Strategies for Anti-Inflammatory Treatment of Noninfectious Arthritis. Adv. Healthcare Mater. 10: e2001732 (2021). doi: 10.1002/adhm.202001732. PMID: 33870656. 
  9. Chamling X, Kallman A, Fang W, Berlinicke CA, Mertz JL, Devkota P, Pantoja IEM, Smith MD, Ji Z, Chang C, Kaushik A, Chen L, Whartenby KA, Calabresi PA, Mao HQ, Ji H, Wang TH, Zack DJ. Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells. Nature Commun. 12(1): 652 (2021). doi: 10.1038/s41467-021-20892-3. PMID: 33510160.
  10. Hu H, Yang C, Li M, Shao D, Mao HQ, Leong KW. Flash technology-based self-assembly in nanoformulation: from fabrication to biomedical applications. Mater Today. 42: 99–116 (2021). doi: 10.1016/j.mattod.2020.08.019. PMID: 34421329.
  11. Chang C, Yan J, Yao Z, Zhang C, Li X, Mao HQ. Effects of mesenchymal stem cell-derived paracrine signals and their delivery strategies. Adv. Healthcare Mater. 10(7): e2001689 (2021). doi: 10.1002/adhm.202001689. PMID: 33433956.


  1. Wilson KL, Howard GP, Coatsworth H, Dinglasan RR, Mao HQ, Plebanski M. Biodegradable PLGA-b-PEG Nanoparticles Induce T Helper 2 (Th2) Immune Responses and Sustained Antibody Titers via TLR9 Stimulation. Vaccines. 8(2): 261. doi: 10.3390/vaccines8020261 (2020). PMID: 32485944.
  2. Wang Y, Cheng L, Wen S, Zhou S, Wang Z, Deng L, Mao HQ, Cui W, Zhang H. Ice-Inspired Superlubricated Electrospun Nanofibrous Membrane for Preventing Tissue Adhesion. Nano Lett. 20(9): 6420–6428 (2020). doi: 10.1021/acs.nanolett.0c01990. PMID: 32813534.
  3. Beh CW, Fu Y, Weiss CR, Hu C, Arepally A, Mao HQ, Wang TH, Kraitchman DL. Microfluidic-prepared, monodisperse, X-ray-visible, embolic microspheres for non-oncological embolization applications. Lab Chip. 20(19): 3591–3600 (2020). doi: 10.1039/d0lc00098a.  PMID: 32869821.
  4. Ke X, Shelton L, Hu Y, Zhu Y, Chow E, Tang H, Santos JL, Mao HQ. Surface-Functionalized PEGylated Nanoparticles Deliver Messenger RNA to Pulmonary Immune Cells. ACS Appl Mater Interfaces. 12(32): 35835–35844 (2020). doi: 10.1021/acsami.0c08268. PMID: 32659078.
  5. Henn D, Chen K, Fischer K, Rauh A, Barrera JA, Kim YJ, Martin RA, Hannig M, Niedoba P, Reddy SK, Mao HQ, Kneser U, Gurtner GC, Sacks JM, Schmidt VJ. Tissue Engineering of Axially Vascularized Soft-Tissue Flaps with a Poly-(ɛ-Caprolactone) Nanofiber-Hydrogel Composite. Adv Wound Care. 9(7): 365–377 (2020). doi: 10.1089/wound.2019.0975. PMID: 32587789.
  6. Hickey JW, Isser A, Salathe SF, Gee KM, Hsiao MH, Shaikh W, Uzoukwu NC, Bieler JG, Mao HQ, Schneck JP. Adaptive Nanoparticle Platforms for High Throughput Expansion and Detection of Antigen-Specific T cells. Nano Lett. 20(9): 6289–6298 (2020). doi: 10.1021/acs.nanolett.0c01511. PMID: 32594746.
  7. Gilbert-Honick J, Iyer SR, Somers SM, Takasuka H, Lovering RM, Wagner KR, Mao HQ, Grayson WL. Engineering 3D skeletal muscle primed for neuromuscular regeneration following volumetric muscle loss. Biomaterials. 255: 120154 (2020). doi: 10.1016/j.biomaterials.2020.120154. PMID: 32562942. 
  8. Morrissette-McAlmon J, Ginn B, Somers S, Fukunishi T, Thanitcul C, Rindone A, Hibino N, Tung L, Mao HQ, Grayson W. Biomimetic Model of Contractile Cardiac Tissue with Endothelial Networks Stabilized by Adipose-Derived Stromal/Stem Cells. Sci Rep. 10(1): 8387 (2020). doi: 10.1038/s41598-020-65064-3. PMID: 32433563.
  9. Hao Y, Seo JH, Hu Y, Mao HQ, Mittal R. Flow physics and mixing quality in a confined impinging jet mixer. AIP Adv. 10(4): 045105 (2020). doi: 10.1063/5.0002125. PMID: 32266109. 
  10. Li X, Zhang C, Haggerty AE, Yan J, Lan M, Seu M, Yang M, Marlow MM, Maldonado-Lasunción I, Cho B, Zhou Z, Chen L, Martin R, Nitobe Y, Yamane K, You H, Reddy S, Quan DP, Oudega M, Mao HQ. The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord. Biomaterials. 245: 119978 (2020). doi: 10.1016/j.biomaterials.2020.119978. PMID: 32217415.
  11. Sun L, Le Z, He S, Liu J, Liu L, Leong KW, Mao HQ, Liu Z, Chen Y. Flash Fabrication of Orally Targeted Nanocomplexes for Improved Transport of Salmon Calcitonin across the Intestine. Mol Pharm. 17(3): 757-768 (2020). doi: 10.1021/acs.molpharmaceut.9b00827. PMID: 32011888.
  12. He Z, Nie T, Hu Y, Zhou Y, Zhu J, Liu Z, Liu L, Leong KW, Chen Y, Mao HQ. A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and reduce cardiovascular complications in a mouse model of type II diabetes. J. Control. Release. 318: 86-97 (2020). pii: S0168-3659(19)30733-3. doi: 10.1016/j.jconrel.2019.12.014. PMID: 31838207.
  13. Chang C, Ginn B, Livingston N, Yao Z, Slavin B, King, M Chung, S, Mao HQ. “Medical Fibers and Biotextiles”, Biomaterials Science, An Introduction to Materials in Medicine; Editors: Wagner WR, Sakiyama-Elbert SE, Zhang G, Yaszemski MJ (4th Edition; Academic Press). 10.1016/B978-0-12-816137-1.00038-6. pp. 575-600 (2020). 


  1. Ke X, Howard GP, Tang H, Cheng B, Saung MT, Santos JL, Mao HQ. Physical and chemical profiles of nanoparticles for lymphatic targeting. Advanced Drug Delivery Reviews. 151-152: 72–93. (2019) doi: 10.1016/j.addr.2019.09.005. PMID: 31626825.
  2. Saung MT, Ke X, Howard GP, Zheng L, Mao HQ. Particulate carrier systems as adjuvants for cancer vaccines. Biomaterials Sciences. 7(12): 4873–4887 (2019). doi: 10.1039/c9bm00871c. PMID: 31528923.
  3. Hu Y, He Z, Hao Y, Gong L, Pang M, Howard GP, Ahn HH, Brummet M, Chen K, Liu HW, Ke X, Zhu J, Anderson CF, Cui H, Ullman CG, Carrington CA, Pomper MG, Seo JH, Mittal R, Minn I, Mao HQ. Kinetic control in assembly of plasmid DNA/polycation complex nanoparticles. ACS Nano. 13 (9): 10161–10178 (2019). PMID: 31503450.
  4. Zhou Z, Long D, Hsu CC, Liu H, Chen L, Slavin B, Lin H, Li X, Tang J, Yiu S, Tuffaha S, Mao HQ. Nanofiber-reinforced decellularized amniotic membrane improves limbal stem cell transplantation in a rabbit model of corneal epithelial defect. Acta Biomaterialia. 97: 310-320 (2019). PMID: 31437637.
  5. Nie T, He Z, Zhou Y, Zhu J, Chen K, Liu L, Leong KW, Mao HQ, Chen Y. Surface coating approach to overcome mucosal entrapment of DNA nanoparticles for oral gene delivery of glucagon-like peptide 1. ACS Applied Materials and Interfaces. 11(33): 29593-29603 (2019). PMID: 31348859.
  6. Guo Y, Gilbert-Honick J, Somers SM, Mao HQ, Grayson WL. Modified cell-electrospinning for 3D myogenesis of C2C12s in aligned fibrin microfiber bundles. Biochemical and Biophysical Research Communications. 516 (2): 558-564 (2019). PMID: 31235253. 
  7. Mi R, Tammia M, Shinn D, Li Y, Martin R, Mao HQ, Höke A. Oligodendrocyte Precursors Gain Schwann Cell-Like Phenotype and Remyelinate Axons Upon Engraftment into Peripheral Nerves. J Tissue Eng. Regen. Med. 2019; doi: 10.1002/term.2935. PubMed PMID: 31306565.
  8. Howard GP, Verma G, Ke X, Thayer WM, Hamerly T, Baxter VK, Lee JE, Dinglasan RR, Mao H-Q. Critical size limit of biodegradable nanoparticles for enhanced lymph node trafficking and paracortex penetration. Nano Research. 2019; 12(4): 837-844. doi: 10.1007/s12274-019-2301-3.
  9. Lopez J, Xin K, Quan A, Xiang S, Leto Barone AA, Budihardjo J, Musavi L, Mulla S, Redett R, Martin R, Mao HQ, Lee WPA, Ibrahim Z, Brandacher G. Poly(ε-Caprolactone) Nanofiber Wrap Improves Nerve Regeneration and Functional Outcomes after Delayed Nerve Repair. Plast. Reconstr. Surg. 2019; 144(1): 48e-57e. doi: 10.1097/PRS.0000000000005715. PubMed PMID: 31246816.
  10. Guo Y, Gilbert-Honick J, Somers SM, Mao HQ, Grayson WL. Modified cell-electrospinning for 3D myogenesis of C2C12s in aligned fibrin microfiber bundles. Biochem. Biophys. Res. Commun. 2019; 516(2): 558-564. doi: 10.1016/j.bbrc.2019.06.082. PubMed PMID: 31235253.
  11. Somers SM, Zhang NY, Morrissette-McAlmon JBF, Tran K, Mao HQ, Grayson WL. Myoblast maturity on aligned microfiber bundles at the onset of strain application impacts myogenic outcomes. Acta Biomater. 2019; 94: 232-242. doi: 10.1016/j.actbio.2019.06.024. PubMed PMID: 31212110.
  12. Kanji S, Das M, Joseph M, Aggarwal R, Sharma SM, Ostrowski M, Pompili VJ, Mao HQ, Das H. Nanofiber-expanded human CD34(+) cells heal cutaneous wounds in streptozotocin-induced diabetic mice. Sci Rep. 2019; 9(1): 8415. doi: 10.1038/s41598-019-44932-7. PubMed PMID: 31182750; PubMed Central PMCID: PMC6557810.
  13. Elliott MB, Ginn B, Fukunishi T, Bedja D, Suresh A, Chen T, Inoue T, Dietz HC, Santhanam L, Mao HQ, Hibino N, Gerecht S. Regenerative and durable small-diameter graft as an arterial conduit. Proc. Natl. Acad. Sci. U. S. A. 2019; 116(26): 12710-12719. doi: 10.1073/pnas.1905966116. PubMed PMID: 31182572; PubMed Central PMCID: PMC6601275.
  14. Sarhane KA, Tuffaha SH, Ibrahim Z, Cashman CR, Krick K, Martin R, Broyles JM, Cooney DS, Lee WPA, Mi R, Mao HQ, Höke A, Brandacher G. Glial Cell Line-Derived Neurotrophic Factor and Chondroitinase Promote Axonal Regeneration in a Chronic Denervation Animal Model. Neurotherapeutics. 2019. doi: 10.1007/s13311-019-00745-0. PubMed PMID: 31148054.
  15. Ke X, Wei Z, Wang Y, Shen S, Ren Y, Williford JM, Luijten E, Mao HQ. Subtle changes in surface-tethered groups on PEGylated DNA nanoparticles significantly influence gene transfection and cellular uptake. Nanomedicine. 2019; 19: 126-135. doi: 10.1016/j.nano.2019.04.004. PubMed PMID: 31048082.
  16. Li X, Cho B, Martin R, Seu M, Zhang C, Zhou Z, Choi JS, Jiang X, Chen L, Walia G, Yan J, Callanan M, Liu H, Colbert K, Morrissette-McAlmon J, Grayson W, Reddy S, Sacks JM, Mao HQ. Nanofiber-hydrogel composite-mediated angiogenesis for soft tissue reconstruction. Sci. Transl. Med. 2019; 11(490). pii: eaau6210. doi: 10.1126/scitranslmed.aau6210. PubMed PMID: 31043572.
  17. Ke X, Tang H, Mao HQ. Effective encapsulation of curcumin in nanoparticles enabled by hydrogen bonding using flash nanocomplexation. Int. J. Pharm. 2019; 564: 273-280. doi: 10.1016/j.ijpharm.2019.04.053. PubMed PMID: 31009696.
  18. Chen S, Du Z, Zou J, Qiu S, Rao Z, Liu S, Sun X, Xu Y, Zhu Q, Liu X, Mao HQ, Bai Y, Quan D. Promoting Neurite Growth and Schwann Cell Migration by the Harnessing Decellularized Nerve Matrix onto Nanofibrous Guidance. ACS Appl. Mater. Interfaces. 2019; 11(19): 17167-17176. doi: 10.1021/acsami.9b01066. PubMed PMID: 31002219.
  19. Negron K, Khalasawi N, Lu B, Ho CY, Lee J, Shenoy S, Mao HQ, Wang TH, Hanes J, Suk JS. Widespread gene transfer to malignant gliomas with In vitro-to-In vivo correlation. J. Control. Release. 2019; 303: 1-11. doi: 10.1016/j.jconrel.2019.04.010. PubMed PMID: 30978431; PubMed Central PMCID: PMC6579670.
  20. Hickey JW, Dong Y, Chung JW, Salathe SF, Pruitt HC, Li X, Chang C, Fraser AK, Bessell CA, Ewald AJ, Gerecht S, Mao HQ*, Schneck JP*. Engineering an artificial T-cell stimulating matrix for immunotherapy. Adv. Mater. 2019 Apr 10: e1807359. doi: 10.1002/adma.201807359. PMID: 30968468 (Cover Article). 
  21. He Z, Hu Y, Gui Z, Zhou Y, Nie T, Zhu J, Liu Z, Chen K, Liu L, Leong KW, Cao P, Chen Y, Mao HQ. Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse model of type II diabetes. J. Controlled Release. 2019; 301: 119-128. doi: 10.1016/j.jconrel.2019.03.014. PMID: 30894322.
  22. Sarhane KA, Ibrahim Z, Martin R, Krick K, Cashman CR, Tuffaha SH, Broyles JM, Prasad N, Yao ZC, Cooney DS, Mi R, Lee WA, Hoke A, Mao HQ, Brandacher G. Macroporous nanofiber wraps promote axonal regeneration and functional recovery in nerve repair by limiting fibrosis. Acta Biomater. 2019; 88: 332-345. doi: 10.1016/j.actbio.2019.02.034. PMID: 30807875.
  23. Miller RJ, Thompson JM, Zheng J, Marchitto MC, Archer NK, Pinsker BL, Ortines RV, Jiang X, Martin RA, Brown ID, Wang Y, Sterling RS, Mao HQ, Miller LS. In vivo bioluminescence imaging in a rabbit model of orthopaedic implant-associated infection to monitor efficacy of an antibiotic-releasing coating. J. Bone Joint Surg. Am. 2019; 101(4): e12. doi: 10.2106/JBJS.18.00425. PMID: 30801375. 
  24. Peng B, Liang H, Li Y, Dong C, Shen J, Mao HQ, Leong KW, Chen Y, Liu L. Tuned Cationic Dendronized Polymer: Molecular Scavenger for Rheumatoid Arthritis Treatment. Angew. Chem. Int. Ed. Engl. 2019 Feb 6. doi: 10.1002/anie.201813362. PMID: 30724436.


  1. Tammia M, Mi R, Sluch VM, Zhu A, Chung T, Shinn D, Zack DJ, Höke A, Mao HQ. Egr2 overexpression in Schwann cells increases myelination frequency in vitro. Heliyon. 2018; 4(11): e00982. doi: 10.1016/j.heliyon.2018.e00982. PMID: 30761371.
  2. Sun L, Liu Z, Tian H, Le Z, Liu L, Leong KW, Mao HQ, Chen Y. Scalable Manufacturing of Enteric Encapsulation Systems for Site-Specific Oral Insulin Delivery. Biomacromolecules. 20(1):528-538 (2019). doi: 10.1021/acs.biomac.8b01530. PMID: 30537806.
  3. Le Z, Chen Y, Han H, Tian H, Zhao P, Yang C, He Z, Liu L, Leong KW, Mao HQ, Liu Z, Chen Y. Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy. ACS Appl Mater Interfaces. 10(49): 42186-42197 (2018). doi: 10.1021/acsami.8b18979. PMID: 30444601.
  4. Zeng Z, Dong C, Zhao P, Liu Z, Liu L, Mao HQ, Leong KW, Gao X, Chen Y. Scalable Production of Therapeutic Protein Nanoparticles Using Flash Nanoprecipitation. Adv Healthc. Mater. 2018 Oct 19: e1801010. doi: 10.1002/adhm.201801010. PMID: 30338666.
  5. Liang H, Peng B, Dong C, Liu L, Mao J, Wei S, Wang X, Xu H, Shen J, Mao HQ, Gao X, Leong KW, Chen Y. Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation. Nat Commun. 2018 Oct 16;9(1):4291. doi: 10.1038/s41467-018-06603-5. PMID: 30327464.
  6. Hickey JW, Isser AY, Vincente FP, Warner SB, Mao HQ, Schneck JP. Efficient magnetic enrichment of antigen-specific T cells by engineering particle properties. Biomaterials. 187: 105–116. Doi: 10.1016/j.biomaterials.2018.09.029 (2018).
  7. Gilbert-Honick J, Ginn B, Zhang Y, Salehi S, Wagner KR, Mao HQ, Grayson WL. Adipose-derived stem/stromal cells on electrospun fibrin microfiber bundles enable moderate muscle reconstruction in a volumetric muscle loss model. Cell Transplant. 27(11): 1644-1656 (2018). doi: 10.1177/0963689718805370. PMID: 30298751. 
  8. He Z, Hu Y, Nie T, Tang H, Zhu J, Chen K, Liu L, Leong KW, Chen Y, Mao HQ. Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery. Acta Biomater. 81: 195-207 (2018). doi: 10.1016/j.actbio.2018.09.047. PMID: 30267888.
  9. Du J, Zhen G, Chen H, Zhang S, Qing L, Yang X, Lee G, Mao HQ, Jia X. Optimal electrical stimulation boosts stem cell therapy in nerve regeneration. Biomaterials. 181: 347-359 (2018). doi: 10.1016/j.biomaterials.2018.07.015. PMID: 30098570.
  10. Zeng Z, Zhao P, Liu L, Gao X, Mao HQ, Chen Y. Lipid stabilized solid drug nanoparticles for targeted chemotherapy. ACS Appl. Mater. Interfaces. 10(30): 24969-24974 (2018). doi: 10.1021/acsami.8b07024. PMID: 30024145.
  11. Tian H, He Z, Sun C, Yang C, Zhao P, Liu L, Leong KW, Mao HQ, Liu Z, Chen Y. Uniform core-shell nanoparticles with thiolated hyaluronic acid coating to enhance oral delivery of insulin. Adv. Healthc. Mater. 7(17): e1800285 (2018). doi: 10.1002/adhm.201800285. PMID: 29984479.
  12. Zou JL, Sun JH, Qiu S, Chen SH, He FL, Li JC, Mao HQ, Liu XL, Quan DP, Zeng YS, Zhu QT. Spatial distribution affects the role of CSPGs in nerve regeneration via the actin filament-mediated pathway. Exp. Neurol. 307: 37-44 (2018). doi: 10.1016/j.expneurol.2018.05.023. PMID: 29852179.
  13. Yao S, Yu S, Cao Z, Yang Y, Yu X, Mao HQ, Wang LN, Sun X, Zhao L, Wang X. Hierarchically aligned fibrin nanofiber hydrogel accelerated axonal regrowth and locomotor function recovery in rat spinal cord injury. Int. J. Nanomedicine. 13: 2883-2895 (2018). doi: 10.2147/IJN.S159356. PMID: 29844671.
  14. Jiang B, Ibrahim A, Martin R, Keet C, Mao H-Q, Hoag SW. Development and validation of an HPLC with fluorescence detection method to quantify the peanut allergen Ara h2 in peanut extract and sublingual films. Separation Science Plus. 1(9): 579–587 (2018).
  15. Qiao D, Liu L, Chen Y, Xue C, Gao Q, Mao HQ, Leong KW, Chen Y. Potency of a scalable nanoparticulate subunit vaccine. Nano Lett. 18(5): 3007-3016 (2018). doi: 10.1021/acs.nanolett.8b00478. PMID: 29694053.
  16. Liu H, Zhou Z, Lin H, Wu J, Ginn B, Choi JS, Jiang X, Chung L, Elisseeff JH, Yiu S, Mao HQ. Synthetic nanofiber-reinforced amniotic membrane via interfacial bonding. ACS Appl. Mater. Interfaces. 10(17): 14559-14569 (2018). doi: 10.1021/acsami.8b03087. PMID: 29613762.
  17. Gilbert-Honick J, Iyer SR, Somers SM, Lovering RM, Wagner K, Mao HQ, Grayson WL. Engineering functional and histological regeneration of vascularized skeletal muscle. Biomaterials. 164: 70-79 (2018). doi: 10.1016/j.biomaterials.2018.02.006. PMID: 29499437.
  18. He Z, Liu Z, Tian H, Hu Y, Liu L, Leong KW, Mao HQ, Chen Y. Scalable production of core-shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral delivery of insulin. Nanoscale 10(7): 3307-3319 (2018). doi: 10.1039/c7nr08047f. PMID: 29384554. 
  19. Jiang X, Overdeep KR, Wainwright ER, Weihs TP, Mao HQ. Effect of humidity on sporicidal activity of iodine vapor on bacillus thuringiensis. Curr. Microbiol. 75(2): 237-246 (2018). doi: 10.1007/s00284-017-1371-2. PMID: 29098371. 
  20. Wang X, Maruotti J, Majumdar S, Roman J, Mao HQ, Zack DJ, Elisseeff JH. Collagen vitrigels with low-fibril density enhance human embryonic stem cell-derived retinal pigment epithelial cell maturation. J. Tissue Eng. Regen. Med. 12(3): 821-829 (2018) doi: 10.1002/term.2598. PMID: 29049869.


  1. Hickey JW, Vicente FP, Howard GP, Mao HQ, Schneck JP. Biologically inspired design of nanoparticle artificial antigen-presenting cells for immunomodulation. Nano Lett. 17(11): 7045-7054 (2017). doi: 10.1021/acs.nanolett.7b03734. PMID: 28994285.
  2. He Z, Santos JL, Tian H, Huang H, Hu Y, Liu L, Leong KW, Chen Y, Mao HQ. Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin. Biomaterials. 130: 28–41. doi: 10.1016/j.biomaterials.2017.03.028. PMID: 28359018 (2017).
  3. Li X, Tzeng SY, Zamboni CG, Koliatsos VE, Ming GL, Green JJ, Mao HQ. Enhancing oligodendrocyte differentiation by transient transcription activation via DNA nanoparticle-mediated transfection. Acta Biomater. 2017; doi: 10.1016/j.actbio.2017.03.032. PMID: 28344151.
  4. Liyanage W, Ardoña HA, Mao HQ, Tovar JD. Cross-linking approaches to tuning the mechanical properties of peptide π-electron hydrogels. Bioconjug Chem. 2017; 28(3): 751-759. doi: 10.1021/acs.bioconjchem.6b00593. PMID: 28292179.
  5. Wu J, Qu W, Williford JM, Ren Y, Jiang X, Jiang X, Pan D, Mao HQ, Luijten E. Improved siRNA delivery efficiency via solvent-induced condensation of micellar nanoparticles. Nanotechnology. doi: 10.1088/1361-6528/aa6519. PMID: 28266928 (2017).
  6. Kashiwabuchi F, Parikh K, Omiadze R, Zhang S, Luo L, Patel H, Xu Q, Ensign L, Mao HQ, Hanes J, McDonnell PJ. Development of absorbable, antibiotic-eluting sutures for ophthalmic surgery. Translational Vision Science & Technology. 6(1): 1. doi: 10.1167/tvst.6.1.1, (2017).


  1. Alyssa G. Ashbaugh AG, Jiang X, Zheng J, Tsai AS, Kim WS, Thompson JM, Miller RJ, Shahbazian JH, Wang Y, Ordonez AA, Chang YS, Jain SK, Jones LC, Sterling RS, Mao HQ*, Miller LS*. Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo. Proceedings of National Academy of Sciences, U. S. A. 113(45): E6919-E6928 (2016)..
  2. Santos JL, Ren Y, Vandermark J, Archang MM, Williford JM, Liu H, Lee J, Wang TH, Mao HQ. Continu
  3. ous production of discrete plasmid DNA-polycation nanoparticles using flash nanocomplexation. Small. 12(45): 6214-6222. doi: 10.1002/smll.201601425 (2016) (Cover Article).Roman JA, Reucroft I, Martin RA, Hurtado A, Mao HQ. Local release of paclitaxel from aligned, electrospun microfibers promotes axonal extension. Advanced Healthcare Materials. 5(20): 2628-2635. doi: 10.1002/adhm.201600415 (2016)
  4. Li X, Kozielski K, Cheng YH, Liu H, Zamboni CG, Green J, Mao HQ. Nanoparticle-mediated conversion of primary human astrocytes into neurons and oligodendrocytes. Biomaterials Science. 4(7): 1100-1112 (2016). doi: 10.1039/c6bm00140h; PMID: 27328202.
  5. Williford JM, Archang MM, Minn I, Ren Y, Wo M, Vandermark J, Fisher PB, Pomper MG, Mao HQ. Critical length of PEG grafts on lPEI/DNA nanoparticles for efficient in vivo delivery. ACS Biomaterials Science and Engineering. 2(4): 567-578 (2016). PMID: 27088129 (Cover Article). 
  6. Cook CA, Huri PY, Ginn BP, Gilbert-Honick J, Somers SM, Temple JP, Mao HQ, Grayson WL. Characterization of a novel bioreactor system for 3D cellular mechanobiology studies. Biotechnol Bioeng. (2016). doi: 10.1002/bit.25946. PMID: 26825810.
  7. Li X, Tzeng SY, Liu X, Tammia M, Cheng YH, Rolfe A, Sun D, Zhang N, Green JJ, Wen X, Mao HQ. Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain. Biomaterials. 84: 157-166 (2016). doi: 10.1016/j.biomaterials.2016.01.037. PMID: 26828681.


  1. Khalifian S, Sarhane KA, Tammia M, Ibrahim Z, Mao HQ, Cooney DS, Shores JT, Lee WP, Brandacher G. Stem cell-based approaches to improve nerve regeneration: potential implications for reconstructive transplantation? Archivum Immunologiae et Therapiae Experimentalis. 63(1): 15-30 (2015).
  2. Shyam R, Ren Y, Lee J, Braunstein KE, Mao HQ*, Wong PC*. Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System. Mol Ther Nucleic Acids. 4: e242. doi: 10.1038/mtna.2015.15 (2015). PMID: 25965552
  3. Williford JM, Santos JL, Shyam R, Mao HQ. Shape Control in Engineering of Polymeric Nanoparticles for Therapeutic Delivery. Biomater Sci. 3(7): 894-907. doi: 10.1039/C5BM00006H (2015). PMID: 26146550.
  4. Barreto-Ortiz SF, Fradkin J, Eoh J, Trivero J, Davenport M, Ginn B, Mao HQ, Gerecht S. Fabrication of 3-dimensional multicellular microvascular structures. FASEB J. 29(8): 3302-14 (2015). doi: 10.1096/fj.14-263343. PMID: 25900808.
  5. Yalanis GC, Reddy S, Martin R, Choi J, Brandacher G, Mao HQ*, Sacks JM*. An Injectable Nanofiber-Hydrogel Composite with Interfacial Bonding for Soft Tissue Filling and Regeneration. Plast Reconstr Surg. 136(4 Suppl): 153-4 (2015). doi: 10.1097/01.prs.0000472477.01873.45. PMID: 26397687. 
  6. Sluch VM, Davis CH, Ranganathan V, Kerr JM, Krick K, Martin R, Berlinicke CA, Marsh-Armstrong N, Diamond JS, Mao HQ, Zack DJ. Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sci Rep. 5: 16595 (2015). doi: 10.1038/srep16595. PMID: 26563826.
  7. Hickey JW, Santos JL, Williford JM, Mao HQ. Control of polymeric nanoparticle size to improve therapeutic delivery. J Control Release. 219: 536-47 (2015). doi: 10.1016/j.jconrel.2015.10.006. PMID: 26450667.


  1. Williford JM, Ren Y, Huang K, Pan D, Mao HQ. Shape transformation following reduction-sensitive PEG cleavage of polymer/DNA nanoparticles. Journal of Materials Chemistry B. Materials in Biology and Medicine. 2(46): 8106-8109 (2014). PMID: 25530853.
  2. Yu YQ, Jiang XQ, Gao S, Ma R, Jin Y, Jin X, Peng SY, Mao HQ, Li JT. Local delivery of VEGF via nanofiber matrix improves liver regeneration after extensive hepatectomy in rats. Journal of Biomedical Nanotechnology. 10(11): 3407-3415 (2014). 
  3. Beh CW, Pan D, Lee J, Jiang X, Liu KJ, Mao HQ, Wang TH. Direct interrogation of DNA content distribution in nanoparticles by a novel microfluidics-based single-particle analysis. Nano Letter. 14(8): 4729-4735 (2014). PMID: 25054542.
  4. Williford JM, Wu J, Ren Y, Archang MM, Leong KW, Mao HQ. Recent advances in nanoparticle-mediated siRNA delivery. Annual Reviews in Biomedical Engineering. 16(7): 347-370 (2014). PMID: 24905873.
  5. Joseph M, Das M, Kanji S, Lu J, Aggarwal R, Chakroborty D, Sarkar C, Yu H, Mao HQ, Basu S, Pompili VJ, Das H. Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices. Biomaterials. 35(30): 8566-8575 (2014). PMID: 25002260.
  6. Gibson M, Beachley V, Coburn J, Bandinelli PA, Mao HQ, Elisseeff J. Tissue extracellular matrix nanoparticle presentation in electrospun nanofibers. Biomedical Research International. 2014: 469120 (2014). doi: 10.1155/2014/469120. PMID: 24971329.
  7. Zhang S, Liu X, Barreto-Ortiz SF, Yu Y, Ginn BP, DeSantis NA, Hutton DL, Grayson WL, Cui FZ, Korgel BA, Gerecht S, Mao HQ. Creating polymer hydrogel microfibres with internal alignment via electrical and mechanical stretching. Biomaterials. 35(10): 3243-3251 (2014). PMID: 24439410.


  1. Barreto-Ortiz SF, Zhang S, Davenport M, Fradkin J, Ginn BP, Mao HQ, Gerecht S. A novel in vitro model for microvasculature reveals regulation of circumferential ECM organization by curvature. PLoS One. 8(11): e81061 (2013). doi: 10.1371/journal.pone.0081061. PMID: 24278378.
  2. Ren YJ, Zhang S, Mi R, Liu Q, Zeng X, Rao M, Hoke A, Mao HQ. Enhanced differentiation of human neural crest stem cells towards the Schwann cell lineage by aligned electrospun fiber matrix. Acta Biomaterialia. 9 (8): 7727-7736 (2013). PMID: 23628775.
  3. Lu J, Kanji S, Aggarwal R, Das M, Joseph M, Wu LC, Mao HQ, Pompili VJ, Hadjiconstantinou M, Das H. Umbilical cord blood-derived hematopoietic stem cells improve dopaminergic neuron morphology in the MPTP-mice. Frontier in Biosciences. 18 (3): 970-981 (2013). PMID: 23747860.
  4. Narmada BC, Kang Y, Venkatraman L, Peng Q, Sakban RB, Nugraha B, Jiang X, Bunte RM, So PT, Tucker-Kellogg L, Mao HQ, Yu H. Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fibrosis. Hum Gene Therapy. 24(5): 508-519 (2013). PMID: 23527815.
  5. Dinglasan RR, Armistead JS, Nyland FJ, Mao HQ. Single-dose microparticle delivery of a malaria transmission-blocking vaccine elicits a long-lasting functional antibody response. Current Molecular Medicine. 13(4): 479-487 (2013). PMID: 23331003.
  6. Tang ZH, Liang S, Potter J, Jiang X, Mao HQ, Li Z. Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic fatty liver disease. Journal of Immunology. 190(4): 1788-1796 (2013). PMID: 23296703.
  7. Jiang X, Qu W, Pan D, Ren Y, Williford JM, Cui H, Luijten E, Mao HQ. Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles. Advanced Materials. 25(2): 227-232 (2013). PMID: 23055399 (Cover Article).
  8. Jiang X, Ren Y, Williford JM, Li Z, Mao HQ. Liver-targeted gene delivery through retrograde intrabiliary infusion. Methods in Molecular Biology. 948: 275-284 (2013). PMID: 23070777.


  1. Aggarwal R, Lu J, Kanji S, Joseph M, Das M, Noble GJ, McMichael BK, Agarwal S, Hart RT, Sun Z, Lee BS, Rosol TJ, Jackson R, Mao HQ, Pompili VJ, Das H. Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities. PLoS ONE.  7(6): e39365 (2012). PMID: 22724005.
  2. Loo Y, Grigsby CL, Yamanaka YJ, Chellappan MK, Jiang X, Mao HQ, Leong KW. Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models. Journal of Controlled Release. 160(1): 48-56 (2012). PMID: 22326811.


  1. Coburn J, Gibson M, Bandalini PA, Laird C, Mao HQ, Moroni L, Seliktar D, Elisseeff J. Biomimetics of the Extracellular Matrix: An Integrated Three-Dimensional Fiber-Hydrogel Composite for Cartilage Tissue Engineering. Smart Structures and Systems. 7(3): 213-222 (2011). PMID: 22287978.
  2. Wall BD, Diegelmann SR, Zhang S, Dawidczyk TJ, Wilson WL, Katz HE, Mao HQ, Tovar JD. Aligned macroscopic domains of optoelectronic nanostructures prepared via shear-flow assembly of peptide hydrogels. Advanced Materials. 23(43): 5009-5014 (2011), PMID: 22180891 (Cover Article).
  3. Krick K, Tammia M, Martin R, Höke A, Mao HQ. Signaling cue presentation and cell delivery to promote nerve regeneration. Current Opinions in Biotechnology. 22(5): 741-746 (2011). PMID: 21531127.
  4. Patil PR, Yu J, Banerjee SR, Ren Y, Leong D, Jiang X, Pomper M, Tsui B, Kraitchman DL, Mao HQ. Probing in vivo trafficking of polymer/DNA micellar nanoparticles using SPECT/CT imaging. Molecular Therapy. 19(9): 1626-1635 (2011). PMID: 21750533 (Cover Article).
  5. Jiang X, Christopherson GT, Mao HQ. The effect of nanofiber surface amine density and conjugate structure on the adhesion and proliferation of human hematopoietic progenitor cells. Interface Focus. 1(10): 725-733 (2011). 
  6. Nakanishi M, Patil R, Ren Y, Shyam R, Wong P, Mao HQ. Enhanced stability and knockdown efficiency of poly(ethylene glycol)-b-polyphosphoramidate/siRNA micellar nanoparticles by co-condensation with sodium triphosphate. Pharmaceutical Research. 28(7): 1723-1732 (2011). PMID: 21387148. 
  7. Dai H, Jiang X, Leong KW, Mao HQ. Transient depletion of Kupffer cells leads to enhanced transgene expression in rat liver following retrograde intrabiliary infusion of plasmid DNA and DNA nanoparticles. Human Gene Therapy. 22(7): 873-878 (2011). PMID: 21091274.
  8. Jiang X, Leong D, Ren Y, Li Z, Torbenson MS, Mao HQ. String-like micellar nanoparticles formed by complexation of PEG-b-PPA and plasmid DNA and their transfection efficiency. Pharmaceutical Research. 28(6): 1317-1327 (2011). PMID: 21499836.
  9. Mahairaki V, Lim SH, Christopherson GT, Xu L, Nasonkin I, Yu C, Mao HQ, Koliatsos VE. Nanofiber Matrices Promote the Neuronal Differentiation of Human Embryonic Stem Cell-Derived Neural Precursors In Vitro. Tissue Engineering, Part A. 17(5-6): 855-863 (2011). PMID: 20973749.

2010 & Before

  1. Ren Y, Jiang X, Pan D, Mao HQ. Charge density and molecular weight of polyphosphoramidate gene carrier are key parameters influencing its DNA compaction ability and transfection efficiency. Biomacromolecules. 11(12): 3432-3439 (2010).
  2. Lim SH, Liu XY, Song H, Yarema KJ, Mao HQ. The effect of nanofiber-guided cell alignment on the preferential differentiation of neural stem cells. Biomaterials. 31(34): 9031-9039 (2010).
  3. Jiang X, Zheng Y, Chen HH, Leong KW, Wang TH, Mao HQ. Dual-sensitive micellar nanoparticles regulate DNA unpacking and enhance gene delivery efficiency. Advanced Materials. 22(23): 2556-2560 (2010).
  4. Jiang X, Lim SH, Mao HQ, Chew SY. Current applications and future perspectives of artificial nerve conduits. Experimental Neurology. 223(1): 86-101 (2010). 
  5. Mao HQ, Lim SH, Zhang S, Christopherson GT, Kam K, Fischer S., “Nanofiber matrix as artificial stem cell niche”, In Biomaterials As Stem Cell Niche as part of a Series: “Studies in Mechanobiology, Tissue Engineering and Biomaterials”, Editor(s): K. Roy and A. Gefen. Springer-Verlag, New York, NY (2010). [Book Chapter]
  6. Das H, George JC, Joseph M, Das M, Abdulhameed N, Blitz A, Khan M, Sakthivel R, Mao HQ, Hoit BD, Kuppusamy P, Pompili VJ. Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model. PLoS One. 4(10): e7325 (2009). PMID: 19809493.
  7. Fischer SE, Mi L, Mao HQ, Harden JL. Biofunctional coatings via targeted covalent cross-linking of associating triblock proteins. Biomacromolecules. 10(9): 2408-2417 (2009). PMID: 19655714. 
  8. Lim SH, Mao HQ. Electrospun scaffolds for stem cell engineering. Advanced Drug Delivery Reviews. 61(12): 1084-1096 (2009). PMID: 19647024.
  9. Das H, Abdulhameed N, Joseph M, Sakthivel R, Mao HQ, Pompili VJ. Ex vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis. Cell Transplantation. 18(3): 305-318 (2009). PMID: 19558779.
  10. Chen HH, Ho YP, Jiang X, Mao HQ, Wang TH, Leong KW. Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET. Nano Today. 4(2): 125-134 (2009).Christopherson GT, Song HJ, Mao HQ. The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. Biomaterials. 30(4): 556-564 (2009)
  11. Sun TM, Du JZ, Yan LF, Mao HQ, Wang J. Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery. Biomaterials. 29(32): 4348–4355 (2008). 
  12. Chen HH, Ho YP, Jiang X, Mao HQ, Wang TH, Leong KW. Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum Dot-FRET. Molecular Therapy. 16(2): 324-332 (2008).
  13. Jiang X, Dai H, Ke CY, Mo X, Torbenson MS, Li Z and Mao HQ. PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion. Journal of Controlled Release. 122: 297–304 (2007).
  14. Lin K, Chua KN, Christopherson GT, Lim S and Mao HQ. Reducing electrospun nanofiber diameter and variability using cationic amphiphiles. Polymer. 48: 6384-6394 (2007).
  15. Fischer SE, Liu X, Mao HQ, Harden JL, Controlling cell adhesion to surfaces via associating bioactive triblock proteins. Biomaterials. 28: 3325–3337 (2007).
  16. Chua KN, Tang YN, Quek CH, Ramakrishna S, Leong KW, Mao HQ. Dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes. Acta Biomaterialia. 3: 643–650 (2007).
  17. Chua KN, Chai C, Lee PC, Ramakrishna S, Leong KW, Mao HQ. Functional Nanofiber Scaffolds with Different Spacers Modulate Adhesion and Expansion of Cryopreserved Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells. Experimental Hematology. 35: 771–781 (2007).
  18. Hoque ME, Mao HQ, Ramakrishna S. Hybrid braided 3-D scaffold for bioartificial liver assist devices. Journal of Biomaterials Science-Polymer Edition. 18(1): 45-58 (2007).
  19. Chu LQ, Mao HQ, Knoll W. In situ characterization of moisture sorption/desorption in thin polymer films using optical waveguide spectroscopy. Polymer. 47(21): 7406-7413 (2006).
  20. Chu LQ, Tan WJ, Mao HQ, Knoll W. Characterization of UV-induced graft polymerization of poly(acrylic acid) using optical waveguide spectroscopy. Macromolecules. 39(25): 8742-8746 (2006). 
  21. Dai H, Jiang X, Tan GCY, Chen Y, Torbenson MT, Leong KW, Mao HQ. Chitosan-DNA Nanoparticles Delivered by Intrabiliary Infusion Enhance Liver-Targeted Gene Delivery. International Journal of Nanomedicine. 1(4): 507-522 (2006). 
  22. Chua KN, Chai C, Lee PC, Tang YN, Ramakrishna S, Leong KW, Mao HQ. Surface-Aminated Electrospun Nanofibers Enhance Adhesion and Expansion of Human Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells. Biomaterials. 27(36): 6043-6051 (2006). 
  23. Jiang XS, Chai C, Zhang Y, Zhuo RX, Mao HQ, Leong KW. Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbilical cord blood CD34+ cells. Biomaterials. 27(13): 2723-2732 (2006).
  24. Jiang X, Dai H, Leong KW, Goh SH, Mao HQ, Yang YY. Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions, Journal of Gene Medicine. 8(4): 477-487 (2006). 
  25. Feng Q, Chai C, Jiang XS, Leong KW, Mao HQ. Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin. Journal of Biomedical Materials Research, Part A. 78(4): 781-791 (2006). 
  26. Lu HF, Lim WS, Zhang PC, Chia SM, Yu H, Mao HQ, Leong KW. Galactosylated PVDF hollow fiber bioreactor for hepatocyte culture, Tissue Engineering. 11(11-12):1667-77 (2005).
  27. Chua KN, Lim WS, Zhang P, Lu H, Wen J, Ramakrishna S, Leong KW, Mao HQ. Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold. Biomaterials. 26(15): 2537-2547 (2005). 
  28. Tan WJ, Teo GP, Liao K, Leong KW, Mao HQ, Chan V. Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface. Biomaterials. 26(8): 891-898 (2005). 
  29. Ng S, Wu YN, Zhou Y, Toh YE, Ho ZZ, Chia SM, Zhu JH, Mao HQ, Yu H. Optimization of 3-D hepatocyte culture by controlling the physical and chemical properties of the extra-cellular matrices. Biomaterials. 26(16): 3153-3163 (2005). 
  30. Zhang PC, Wang J, Leong KW, Mao HQ. Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups improve transfection efficiency. Biomacromolecules. 6(1): 54-60 (2005). 
  31. Zhang XQ, Wang XL, Huang SW, Zhuo RX, Liu Z, Mao HQ, Leong KW. In vitro gene delivery using PAMAM dendrimers with trimesyl core. Biomacromolecules. 6(1): 341-350 (2005). 
  32. Zhang XQ, Wang XL, Zhang PC, Liu Z, Zhuo RX, Mao HQ, Leong KW. Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes, Journal of Controlled Release. 102(3): 749-763 (2005).
  33. Mao HQ, Leong KW, Design of poly(phosphoester) nanoparticles for nonviral gene therapy. Advances in Genetics. 53: 275-306 (2005). 
  34. Chia SM, Lin P, Quek CH, Yin C, Mao HQ, Leong KW, Xu X, Goh CH, Ng M, Yu H. Engineering microenvironment for expansion of sensitive anchorage-dependent mammalian cells. Journal of Biotechnology. 118(4): 434-447 (2005). 
  35. Fang N, Tan WJ, Leong KW, Mao HQ, Chan V. pH-responsive adhesion of phospholipid vesicle on poly(acrylic acid) cushion grafted to poly(ethylene terephthalate) surface. Colloids Surf B Biointerfaces. 42(3-4): 245-252 (2005). 
  36. Lu HF, Chua KN, Zhang PC, Lim WS, Ramakrishna S, Leong KW, Mao HQ. Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance. Acta Biomaterialia. 1(5): 399-410 (2005). 
  37. Mao HQ, Shipanova I, Zhao Z, Dang W, Brown A, Leong KW. Biodegradable poly(terephthalate-co-phosphate)s: Synthesis, characterization and drug release properties. Journal of Biomaterials Science-Polymer Edition. 16(2): 135-161 (2005).
  38. Wang J, Gao SJ, Zhang PC, Wang S, Mao HQ, Leong KW. Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency. Gene Therapy. 11(12): 1001-1010 (2004). 
  39. Huang SW, Wang J, Zhang PC, Mao HQ, Zhuo RX, Leong KW. Water-soluble and nonionic polyphosphoester: synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle. Biomacromolecules. 5(2): 306-311 (2004). 
  40. Li Y, Wang J, Lee CG, Wang CY, Gao SJ, Tang GP, Ma YX, Yu H, Mao HQ, Leong KW, Wang S. CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes. Gene Therapy. 11(1): 109-114 (2004). 
  41. Quek CH, Li J, Sun T, Chan ML, Mao HQ, Gan LM, Leong KW, Yu H. Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation. Biomaterials. 25(17): 3531-40 (2004). 
  42. Wan AC, Mao HQ, Wang S, Phua SH, Lee GP, Pan J, Lu S, Wang J, Leong KW. Poly(phosphoester) ionomers as tissue-engineering scaffolds. Journal of Biomedical Materials Research. 70B(1): 91-102 (2004).
  43. Wang J, Lee IL, Lim WS, Chia SM, Yu H, Leong KW, Mao HQ. Evaluation of collagen and methylated collagen as gene carriers. International Journal of Pharmaceutics. 279(1-2): 115-126 (2004). 
  44. Wen J, Mao HQ, Li W, Lin KY, Leong KW. Biodegradable polyphosphoester micelles for gene delivery. Journal of Pharmaceutical Sciences. 93(8): 2142-2157 (2004).
  45. Mao HQ and Leong KW, “Polymeric scaffolds for tissue engineering,” in Frontiers in Biomedical Engineering, Eds. Huang N and Woo S, Kluwer Academic / Plenum Publishers, New York, NY (2004). [Book Chapter]
  46. Ying L, Yin C, Zhuo RX, Leong KW, Mao HQ, Kang ET, Neoh KG. Immobilization of galactose ligands on acrylic acid graft-copolymerized poly(ethylene terephthalate) film and its application to hepatocyte culture. Biomacromolecules. 4(1): 157-165 (2003). 
  47. Yin C, Liao K, Mao HQ, Leong KW, Zhuo RX, Chan V. Adhesion contact dynamics of HepG2 cells on galactose immobilized substrates. Biomaterials. 24(5): 837-850 (2003).
  48. Yin C, Chia SM, Quek CH, Yu H, Zhuo RX, Leong KW, Mao HQ. Microcapsules with improved mechanical stability for hepatocyte culture. Biomaterials. 24(10): 1771-1780 (2003). 
  49. Fang N, Wang J, Mao HQ, Leong KW, Chan V. BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer. Colloids and Surfaces B: Biointerfaces. 29(4): 233-245 (2003). 
  50. Xu X, Yee WC, Hwang PYK, Yu H, Wan ACA, Gao S, Boon KL, Mao HQ, Leong KW, Wang S. Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits. Biomaterials. 24(13): 2405-2412 (2003). 
  51. Zhao Z, Wang J, Mao HQ, Leong KW. Polyphosphoesters in drug and gene delivery. Advanced Drug Delivery Reviews. 55(4): 483-499 (2003). 
  52. Chew JL, Wolfowicz CB, Mao HQ, Leong KW, Chua KY. Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. Vaccine. 21(21-22): 2720-2729 (2003). 
  53. Hu JJ, Yin C, Mao HQ, Tamada K, Knoll WG. Functionalization of poly(ethylene terephthalate) film by pulsed plasma deposition of maleic anhydride. Advanced Functional Materials. 13(9): 692-697 (2003). 
  54. Lu HF, Lim WS, Zhang PC, Wang J, Tang ZQ, Chia SM, Yu H, Leong KW, Mao HQ. Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance. Biomaterials. 24(27): 4893-4903 (2003). 
  55. Yin C, Ying L, Zhang PC, Zhuo RX, Kang ET, Leong KW, Mao HQ. High density of immobilized galactose ligand enhances hepatocyte attachment and function. Journal of Biomedical Materials Research. 67A(4): 1093-1104 (2003). 
  56. Wang J, Huang SW, Zhang PC, Mao HQ, Leong KW. Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters. International Journal of Pharmaceuticals. 265(1-2): 75-84 (2003). 
  57. Fang N, Chan V, Wan KT, Mao HQ, Leong KW. Colloidal adhesion of phospholipid vesicles: high-resolution reflection interference contrast microscopy and theory. Colloids and Surfaces B: Biointerfaces. 25(4): 347-362 (2002). 
  58. Chia SM, Wan ACA, Quek CH, Mao HQ, Xu X, Shen L, Ng ML, Leong KW, Yu H. Multi-layer live cell microcapsules for tissue engineering. Biomaterials. 23(3): 849-856 (2002). 
  59. Xu XY, Yu H, Mao HQ, Gao S, Leong KW, Wang S. Polyphosphoester microspheres for sustained release of biologically active nerve growth factor. Biomaterials. 23(17): 3765-3772 (2002). 
  60. Wang J, Zhang PC, Lu HF, Ma N, Wang S, Mao HQ, Leong KW. New polyphosphoramidate with spermidine side chain mediates efficient gene transfer. Journal of Controlled Release. 83(1): 157-168 (2002). 
  61. Wang J, Zhang PC, Mao HQ, Leong KW. Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier. Gene Therapy. 9(18): 1254-1261 (2002). 
  62. Fang N, Chan V, Mao HQ, Leong KW. Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH. Biomacromolecules. 2(4): 1161-1168 (2001). 
  63. Chan V, Mao HQ, Leong KW. Chitosan-induced perturbation of dipalmitoyl-sn-glycero-3-phosphocholine membrane bilayer. Langmuir. 17(12): 3749-3756 (2001). 
  64. Wang S, Wan ACA, Xu XY, Gao SJ, Mao HQ, Leong KW, Yu H. A new nerve guide conduit material composed of a biodegradable poly(phosphoester). Biomaterials. 22(10): 1157-69 (2001). 
  65. Wan ACA, Mao HQ, Wang S, Leong KW, Ong L, Yu H. Fabrication of poly(phosphoester) nerve guides by immersion precipitation and the control of porosity. Biomaterials. 22(10): 1147-56 (2001). 
  66. Wang J, Mao HQ, Leong KW. A novel biodegradable gene carrier based on polyphosphoester. Journal of the American Chemical Society. 123(38): 9480-9481 (2001). 
  67. Mao HQ, Roy K, Truong-Le VL, Janes K, Lin KY, Wang Y, August JT, Leong KW. Chitosan-DNA nanoparticles as gene delivery vehicles. Journal of Controlled Release. 70(3): 399-421 (2001). 
  68. Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan-DNA nanoparticles generates immunological protection in a murine model of peanut allergy. Nature Medicine. 5(4): 387-391 (1999). 
  69. Truong-Le VL, Walsh SM, Schweibert E, Mao HQ, Guggino WB, August JT, Leong KW. Gene transfer by DNA-gelatin nanosphere. Archives of Biochemistry and Biophysics. 361(1): 47-56 (1999). 
  70. Mao HQ, Zhao Z, Dang W, Shipanova-Kadiyala I, Leong KW. “Biodegradable poly(phosphoester)s”, in Encyclopedia of Controlled Drug Delivery. pp. 45-60. First Edition, Ed. E. Mathiowitz, Johns Wiley & Sons, Inc. New York, NY (1999). [Book Chapter]
  71. Leong KW, Mao HQ, Truong-Le VL, Roy K, Walsh SM, August JT. DNA nanospheres as non-viral gene delivery vehicles. Journal of Controlled Release. 53(1): 183-193 (1998). 
  72. Zhuo RX, Wang J, Mao HQ, Zang C, Ye Y. Immunomodulation of synthesized polymers containing phosphorus in the backbone-Effect on the proliferation of lymphocytes. Chinese Journal of Reactive Polymers. 6(1): 67-76 (1997).
  73. Zhuo RX, Wang J, Mao HQ. Syntheses of poly(phosphate-urethane)s as drug release materials. Chemical Journal of Chinese Universities. 18 (7): 1207-1211 (1997).
  74. Leong KW, Mao HQ, Zhuo RX, Biodegradable polymers with a phosphoryl-containing backbone: tissue engineering and controlled drug delivery applications. Chinese Journal of Polymer Science. 13(4): 289-314 (1995). 
  75. Mao HQ, Zhuo RX, Fan CL, Jiang XS, Liu WP, Yi H, Studies on the phosphorylating polycondensation catalyzed by 4-dimethylaminopyridine, Macromolecular Chemistry and Physics. 196: 655-658 (1995).
  76. Mao HQ, Zhuo RX, Fan CL, Fan LH, Fu YP. Synthesis of new polyphosphates as drug release materials. Chemical Journal of Chinese Universities. 14(12): 1743-1747 (1993).
  77. Mao HQ, Zhuo RX, Fan CL. Synthesis and biological properties of polymer immunoadjuvants. Polymer Journal. 25(5): 499-506 (1993).


  1. Russell Martin, Hai-Quan Mao. In situ forming composite material for tissue restoration. United States Patent 20230338612A1 (Filed on May 15, 2018; Published on July 26, 2022; Granted on Oct 26, 2023).
  2. Xuesong Jiang, Sashank Reddy, Gerald Brandacher, Hai-Quan Mao, Justin Sacks, Xiaowei Li, Kevin Feng, Russell Martin, Georgia C. Yalanis, Ji Suk Choi. Composite material for tissue restoration. United States Patent 20230293776A1 (Filed on Aug 17, 2015; Published on May 22, 2023; Granted on Sep 21, 2023).
  3. Sharon Gerecht, Morgan B. Elliott, Hai-Quan Mao, Jessica Shen. Improved mechanical properties of implantable vascular grafts. United States Patent 20230270919A1 (Filed on Oct 15, 2019; Published on Oct 15, 2020; Granted on Aug 31, 2023).
  4. Jonathan Schneck, Hai-Quan Mao, John Wirthlin Hickey, Ariel Isser. Adaptive nanoparticle platforms for high throughput expansion and detection of antigen-specific T cells. United States Patent 20230243825A1 (Filed on Jun 26, 2020; Published on Jun 23, 2021; Granted on Aug 3, 2023).
  5. Rajat Mittal, Jung Hee Seo, Hai-Quan Mao, Yue Hao, Yizong Hu. Axisymmetric confined impinging jet mixer. United States Patent 20230219044A1 (Filed on Jun 10, 2020; Published on Jun 10, 2021; Granted on Jul 13, 2023).
  6. Hai-Quan Mao, Jose Luis Santos, Zhiyu He, Huahua Huang, Lixin Liu, Kam W. Leong, Yongming Chen. Therapeutic protein-loaded nanoparticle and method for preparing the same. United States Patent 20230190665A1 (Filed on Jan 19, 2017; Granted on Jun 22, 2023).
  7. Hai-Quan Mao, Jose Luis Santos, Yong Ren, John-Michael Williford. Methods of preparing polyelectrolyte complex nanoparticles. United States Patent 20230190667A1 (Filed on Jul 27, 2016; Published on Feb 07, 2023; Granted on Jun 22, 2023).
  8. Huanhuan Liu, Juan Wu, Brian Ginn, Hai-Quan Mao. Composite membrane comprising a decellularized amniotic membrane and a method for preparing the same. United States Patent 11628238B2 (Filed on Jul 14, 2017; Published on Jun 11, 2020; Granted on Apr 18, 2023).
  9. Christos Georgiades, Shin-Jae Lee, Iyer Siddharth, Mathias Insley, Xingyu Jasmine Hu, Da In Diane Lee, Hai-Quan Mao. Composite materials and embolization methods. United States Patent 20230080504A1 (Filed on Jan 16, 2020; Published on Jan 15, 2021; Granted on Mar 16, 2023).
  10. Hai-Quan Mao, Gregory P. Howard. Compositions of alum nanoparticles for immunomodulation and methods for producing the same. United States Patent 20230083448A1 (Filed on Feb 07, 2020; Published on Feb 05, 2021; Granted on Mar 16, 2023).
  11. Florin M. Selaru, Hai-Quan Mao, Ling Li, Yang Zhou, Zhiyu He, Kuntao Chen. Bortezomib-loaded nanoparticles. United States Patent 20230074885A1 (Filed on Feb 05, 2020; Published on Feb 05, 2021; Granted on Mar 09, 2023).
  12. Hai-Quan Mao, Jose Luis Santos, Yong Ren, John-Michael Williford. Methods of preparing polyelectrolyte complex nanoparticles. United States Patent 11395805 B2 (Filed on August 13, 2015; Published on September 30, 2019; Granted on July 26, 2022).
  13. Russell Martin, Hai-Quan Mao. In situ forming composite material for tissue restoration, European Patent EP-3337464-B1 (Filed on August 17, 2015; Published on August 17, 2016; Granted on March 9, 2022).
  14. Mao HQ, Williford JM, Archang M, Minn I, Ren Y, Santos JL, Pomper MG. Compositions of nucleic acid-containing nanoparticles for in vivo delivery. United States Patent 11,235,071 (Filed on February 7, 2018; Published on June 28, 2018); Granted on February 1, 2022.
  15. Miller LS, Mao HQ, Ashbaugh A, Jiang X, Zheng J. Compositions and Methods for Preparation of Composite Polymer Coatings on Medical Implants, and Their Use for Co-Delivery of Multiple Antimicrobial Agents. United States Patent 11,135,340 (Filed on February 8, 2017; Published on August 17, 2017); Granted on October 5, 2021.
  16. Zuhaib I, Mao HQ, Krick K, Martin R, Brandacher G, Sarhane KA. Device and method for a nanofiber wrap to minimize inflammation and scarring. United States Patent 10,500,305. Filed on April 9, 2015; Granted on December 10, 2019.
  17. Martin R, Reddy S, Sacks J, Li X, Cho BH, Mao HQ. Fiber-hydrogel composite surgical meshes for tissue repair. United States Patent 10,471,181. Filed on August 17, 2016; Granted on November 12, 2019; published on 2/13/2020.
  18. Kashiwabuchi FK, Hanes J, Mao HQ, McDonnell PJ, Xu Q, Zhang S, Parikh KS. Methods of making drug loaded microfiber sutures for ophthalmic application. United States Patent 10,471,172. Filed on December 12, 2016; Granted on November 12, 2019.
  19. Jiang X, Reddy S, Brandacher G, Mao, HQ, Sacks J, Li X, Feng K, Martin R, Yalanis GC, Choi JS. Composite material for tissue restoration, United States Patent 10,463,768 (Filed on February 14, 2017; Granted on November 5, 2019).
  20. Mao, HQ, Santos JL, Ren Y, Williford JM. Methods of preparing polyelectrolyte complex nanoparticles. US Patent 10,441,549 (Filed on July 27, 2016; Granted on October 15, 2019; Published on 4/2/2020).
  21. Mao, HQ, Zhang S, Liu X, Ginn BP, Method for preparing electro-mechanically stretched hydrogel microfibers. U.S. Patent 10,119,202; PCT/US2013/038805 (Filed on April 30, 2013. Granted on November 6, 2018).
  22. Hoke A, Lim SH, Liu X, Mao, HQ. Biodegradable Nerve Guides. U.S. Patent 9,707,000 B2 (Filed on November 15, 2013, Granted on July 18, 2017).
  23. Wood R, Mao, HQ, Keet C, Martin R. Orally dissolving thin films containing allergens and methods of making and use. U.S. Patent 9539334 B2 (PCT/US2013/041552) (Filed on May 17, 2013, Granted on January 10, 2017).
  24. Hoke A, Mao, HQ. Biological Tissue Connection and Repair Devices and Methods of Using Same. U.S. Patent 9,539,009 B2 (Filed on December 6, 2013, Granted on January 10, 2017).
  25. Kashiwabuchi FK, Hanes J, Mao, HQ, McDonnell PJ, Patel H, Rodrigues MW, Vidauri-Martinez J, Xu Q, Zhang S. Drug Loaded Microfiber Sutures for Ophthalmic Application. U.S. Patent 9,533,068 B2 (Filed on May 6, 2013, Granted on January 3, 2017).
  26. Sakthivel R, Brown DJ, Mao, HQ, Douay L, Pompili VJ, McIntosh K, Das H, Zhao Y. Erythrocytes differentiated in vitro from nanofiber expanded CD133+ cells. U.S. Patent 8,669,106 (Granted on March 11, 2014).
  27. Mao, HQ, Leong KW, Chua KN, Ramakrishna S. Compositions and methods for the expansion and differentiation of stem cells. U.S. Patent 8,361,502 B2 (Granted on January 29, 2013).
  28. Wang J, Mao HQ, Leong KW. Biodegradable polyphosphoramidates for controlled release of bioactive substances. U.S. Patent 7,417,110 (Granted on August 26, 2008).
  29. Wang J, Mao HQ, Leong KW. Biodegradable polyphosphates for controlled release of bioactive substances. U.S. Patent 7,345,138 (Granted on March 18, 2008).
  30. Li WP, Mao HQ, Leong KW. Controlled delivery of therapeutic agents by insertable medical devices. U.S. Patent 6,899,731 (Granted on May 31, 2005).
  31. Leong KW, Wen J, Mao HQ. Biologically useful polyphosphates. U.S. Patent 6,852,709 (Granted on February 8, 2005).
  32. Leong KW, Wen J, Zhuo RX, Mao HQ. Phosphate based biodegradable polymers. U.S. Patent 6,805,876 (Granted on Oct. 19, 2004).
  33. Dang W, Mao HQ, Shipanova-Kadiyala I, Leong KW, Zhao Z, English JP. Biodegradable compositions comprising poly(cyclo-aliphatic phosphoester) compounds, articles, and method for using the same. U.S. Patent 6,800,672 (Granted on October 5, 2004); WIPO Patent WO9848859A1 (Granted on Nov. 5, 1998).
  34. Mao HQ, Leong KW, Dang W, Lo H, Zhao Z, Nowotnik DP, English JP. Biodegradable terephthalate polyester-poly(phosphate) copolymers, compositions, articles, and methods for making and using the same. U.S. Patent 6,600,010 (Granted on July 29, 2003); WIPO Patent WO9844021A1 (Granted on Oct. 8, 1998).
  35. Mao HQ, Lin KY, Hendriks BS, Leong KW, Haller MF. Polymers for delivery of nucleic acids. U.S. Patent 6,548,302 B1 (Granted on Apr. 15, 2003); WIPO Patent WO9965531A1 (Granted on Dec. 23, 1999).
  36. Mao HQ, Leong KW, Zhao Z, Dang W, English JP, Nowotnik DP. Biodegradable terephthalate polyester-poly(phosphonate) compositions, articles, and methods of using the same. U.S. Patent 6,485,737 (Granted on November 26, 2002); WIPO Patent WO 0019976A2 (Granted on April 13, 2000).
  37. Mao HQ, Leong KW, Zhao Z, Dang W, English JP, Nowotnik DP. Biodegradable terephthalate polyester-poly(phosphite) compositions, articles, and methods of using the same. U.S. Patent 6,419,709B1 (Granted on Jul. 16, 2002); WIPO Patent WO 0019976A2 (Granted on April 13, 2000).
  38. Mao HQ, Zhao Z, English JP, Leong KW. Biodegradable polymers chain-extended by phosphoesters, compositions, articles and methods for making and using the same. U.S. Patent 6,376,644 B1 (Granted on Apr. 23, 2002); WIPO Patent WO9844020A1 (Granted on Oct. 8, 1998).
  39. Mao HQ, Leong KW. Biodegradable polymers, compositions, articles and methods for making and using the same. U.S. Patent 6,238,687 (Granted on May 29, 2001).
  40. Zhao Z, Mao HQ, Leong KW. Two-stage solution polymerization of high molecular weight poly(phosphoesters). U.S. Patent 6,008,318 (Granted on Dec. 28, 1999); WIPO Patent WO9858012A1 (Granted on Dec 23, 1998).
  41. Mao HQ, Wang Y, Byrne B, Leong KW. Knobby nanospheres. WIPO Patent WO9856363A1 (Granted on Dec. 17, 1998).
  42. Mao HQ, Leong KW. Biodegradable poly(phosphoester-co-desamino-tyrosyl-L-tyrosine ester) compounds, compositions, articles and methods for making and using the same. U.S. Patent 5,912,225 (Granted on Jun. 15, 1999); WIPO Patent WO9846286A1 (Granted on Oct. 22, 1998).
  43. Mao HQ, Roy K, Truong VL, August JT, Leong KW. Gene delivery system. U.S. Patent 5,972,707 (Granted on Oct. 26, 1999); WIPO Patent WO9801162A2 (Granted on Jan. 15, 1998).