Yining Zhu
Ph.D. student
Ph.D. Candidate in Biomedical Engineering, School of Medicine
Yining currently serves as the Lab Captain for Mao Lab. He received his B.S. in Pharmacy from the Sichuan University in 2019, and M.S. in Biomedical Engineering from Johns Hopkins University in 2021. As an undergraduate, Yining worked on constructing a nanosystem to co-deliver photosensitizer and immune adjuvant for cancer immunotherapy. In Mao Lab, his thesis research focuses on developing and optimizing lipid nanoparticles with tailored compositions and properties for gene medicine and vaccine delivery. In his free time, Yining enjoys movie and traveling.
Publications:
- Zhu Y*, Cai SS*, Ma J, et al. Optimization of lipid nanoparticles for gene editing of the liver via intraduodenal delivery. Biomaterials, 2024: 122559.
- Zhu Y, Ma J, Shen R, Lin J, Li S, Lu X, Stelzel JL, Kong J, Cheng L, Vuong I, Yao ZC, Wei C, Korinetz NM, Toh WH, Choy J, Reynolds RA, Shears MJ, Cho WJ, Livingston NK, Howard GP, Hu Y, Tzeng SY, Zack DJ, Green JJ, Zheng L, Doloff JC, Schneck JP, Reddy SK, Murphy SC, Mao HQ. Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity. Nat. Biomed. Eng. 2023 Dec; PMID: 38082180.
- Zhu Y, Shen R, Vuong I, Reynolds RA, Shears MJ, Yao ZC, Hu Y, Cho WJ, Kong J, Reddy SK, Murphy SC, Mao HQ. Multi-step screening of DNA/lipid nanoparticles and co-delivery with siRNA to enhance and prolong gene expression. Nat. Commun. 2022 Jul; 13(1): 4282. PMID: 35879315.
- Hu Y*, Zhu Y*, Sutherland ND, Wilson DR, Pang M, Liu E, Staub JR, Berlinicke CA, Zack DJ, Green JJ, Reddy SK, Mao HQ. Size-controlled and shelf-stable DNA particles for production of lentiviral vectors. Nano Lett. 2021 Jul; 21(13): 5697–5705. PMID: 34228937.