Publications

Biomaterials for Therapeutic Engineering   |   Biomaterials for Regenerative Engineering   |   Biomaterials for Immunoengineering   |   Biomaterials Synthesis and Processing

Patents

Pubmed    |   Google Scholar  |   Issued US Patents

Total citations: 10,000; h-index: 50 (December 1, 2016)

Biomaterials for Therapeutic Engineering

Nucleic Acids  |  Nanoparticles  |  Micelles  |  Self-assembly  |  Gene delivery  |   RNAi

  1. Santos JL, Ren Y, Vandermark J, Archang MM, Williford JM, Liu H, Lee J, Wang TH, Mao HQ. Continuous production of discrete plasmid DNA-polycation nanoparticles using flash nanocomplexation. Small. In press (2016) (Cover Article).
  2. Williford JM, Archang MM, Minn I, Ren Y, Wo M, Vandermark J, Fisher PB, Pomper MG, Mao HQ. Critical length of PEG grafts on lPEI/DNA nanoparticles for efficient in vivo delivery. ACS Biomaterials Science and Engineering. 2(4): 567-578 (2016). PMID: 27088129 (Cover Article).
  3. Shyam R, Ren Y, Lee J, Braunstein KE, Mao HQ*, Wong PC*. Intraventricular Delivery of siRNA Nanoparticles to the Central Nervous System. Mol Ther Nucleic Acids. 4: e242. doi: 10.1038/mtna.2015.15 (2015). PMID: 25965552
  4. Williford JM, Santos JL, Shyam R, Mao HQ. Shape Control in Engineering of Polymeric Nanoparticles for Therapeutic Delivery. Biomater Sci. 3(7): 894-907. doi: 10.1039/C5BM00006H (2015). PMID: 26146550.
  5. Williford JM, Ren Y, Huang K, Pan D, Mao HQ. Shape transformation following reduction-sensitive PEG cleavage of polymer/DNA nanoparticles. Journal of Materials Chemistry B. Materials in Biology and Medicine. 2(46): 8106-8109 (2014). PMID: 25530853.
  6. Beh CW, Pan D, Lee J, Jiang X, Liu KJ, Mao HQ, Wang TH. Direct interrogation of DNA content distribution in nanoparticles by a novel microfluidics-based single-particle analysis. Nano Letter. 14(8): 4729-4735 (2014). PMID: 25054542.
  7. Williford JM, Wu J, Ren Y, Archang MM, Leong KW, Mao HQ. Recent advances in nanoparticle-mediated siRNA delivery. Annual Reviews in Biomedical Engineering. 16(7): 347-370 (2014). PMID: 24905873.
  8. Narmada BC, Kang Y, Venkatraman L, Peng Q, Sakban RB, Nugraha B, Jiang X, Bunte RM, So PT, Tucker-Kellogg L, Mao HQ, Yu H. Hepatic stellate cell-targeted delivery of hepatocyte growth factor transgene via bile duct infusion enhances its expression at fibrotic foci to regress dimethylnitrosamine-induced liver fibrosis. Hum Gene Therapy. 24(5): 508-519 (2013). PMID: 23527815.
  9. Jiang X, Qu W, Pan D, Ren Y, Williford JM, Cui H, Luijten E, Mao HQ. Plasmid-templated shape control of condensed DNA-block copolymer nanoparticles. Advanced Materials. 25(2): 227-232 (2013). PMID: 23055399 (Cover Article).
  10. Jiang X, Ren Y, Williford JM, Li Z, Mao HQ. Liver-targeted gene delivery through retrograde intrabiliary infusion. Methods in Molecular Biology. 948: 275-284 (2013). PMID: 23070777.
  11. Loo Y, Grigsby CL, Yamanaka YJ, Chellappan MK, Jiang X, Mao HQ, Leong KW. Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models. Journal of Controlled Release. 160(1): 48-56 (2012). PMID: 22326811.
  12. Patil PR, Yu J, Banerjee SR, Ren Y, Leong D, Jiang X, Pomper M, Tsui B, Kraitchman DL, Mao HQ. Probing in vivo trafficking of polymer/DNA micellar nanoparticles using SPECT/CT imaging. Molecular Therapy. 19(9): 1626-1635 (2011). PMID: 21750533 (Cover Article).
  13. Nakanishi M, Patil R, Ren Y, Shyam R, Wong P, Mao HQ. Enhanced stability and knockdown efficiency of poly(ethylene glycol)-b-polyphosphoramidate/siRNA micellar nanoparticles by co-condensation with sodium triphosphate. Pharmaceutical Research. 28(7): 1723-1732 (2011). PMID: 21387148.
  14. Dai H, Jiang X, Leong KW, Mao HQ. Transient depletion of Kupffer cells leads to enhanced transgene expression in rat liver following retrograde intrabiliary infusion of plasmid DNA and DNA nanoparticles. Human Gene Therapy. 22(7): 873-878 (2011). PMID: 21091274.
  15. Jiang X, Leong D, Ren Y, Li Z, Torbenson MS, Mao HQ. String-like micellar nanoparticles formed by complexation of PEG-b-PPA and plasmid DNA and their transfection efficiency. Pharmaceutical Research. 28(6): 1317-1327 (2011). PMID: 21499836.
  16. Jiang X, Zheng Y, Chen HH, Leong KW, Wang TH, Mao HQ. Dual-sensitive micellar nanoparticles regulate DNA unpacking and enhance gene delivery efficiency. Advanced Materials. 22(23): 2556-2560 (2010).
  17. Ren Y, Jiang X, Pan D, Mao HQ. Charge density and molecular weight of polyphosphoramidate gene carrier are key parameters influencing its DNA compaction ability and transfection efficiency. Biomacromolecules. 11(12): 3432-3439 (2010).
  18. Chen HH, Ho YP, Jiang X, Mao HQ, Wang TH, Leong KW. Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET. Nano Today. 4(2): 125-134 (2009).
  19. Sun TM, Du JZ, Yan LF, Mao HQ, Wang J. Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery. Biomaterials. 29(32): 4348–4355 (2008).
  1. Chen HH, Ho YP, Jiang X, Mao HQ, Wang TH, Leong KW. Quantitative comparison of intracellular unpacking kinetics of polyplexes by a model constructed from quantum Dot-FRET. Molecular Therapy. 16(2): 324-332 (2008).
  2. Jiang X, Dai H, Ke CY, Mo X, Torbenson MS, Li Z and Mao HQ. PEG-b-PPA/DNA micelles improve transgene expression in rat liver through intrabiliary infusion. Journal of Controlled Release. 122: 297–304 (2007).
  3. Dai H, Jiang X, Tan GCY, Chen Y, Torbenson MT, Leong KW, Mao HQ. Chitosan-DNA Nanoparticles Delivered by Intrabiliary Infusion Enhance Liver-Targeted Gene Delivery. International Journal of Nanomedicine. 1(4): 507-522 (2006).
  4. Jiang X, Dai H, Leong KW, Goh SH, Mao HQ, Yang YY. Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions, Journal of Gene Medicine. 8(4): 477-487 (2006).
  5. Zhang PC, Wang J, Leong KW, Mao HQ. Ternary complexes comprising polyphosphoramidate gene carriers with different types of charge groups improve transfection efficiency. Biomacromolecules. 6(1): 54-60 (2005).
  6. Zhang XQ, Wang XL, Huang SW, Zhuo RX, Liu Z, Mao HQ, Leong KW. In vitro gene delivery using PAMAM dendrimers with trimesyl core. Biomacromolecules. 6(1): 341-350 (2005).
  7. Zhang XQ, Wang XL, Zhang PC, Liu Z, Zhuo RX, Mao HQ, Leong KW. Galactosylated ternary DNA/polyphosphoramidate nanoparticles mediate high gene transfection efficiency in hepatocytes, Journal of Controlled Release. 102(3): 749-763 (2005).
  8. Mao HQ, Leong KW, Design of poly(phosphoester) nanoparticles for nonviral gene therapy. Advances in Genetics. 53: 275-306 (2005).
  9. Wang J, Gao SJ, Zhang PC, Wang S, Mao HQ, Leong KW. Polyphosphoramidate gene carriers: effect of charge group on gene transfer efficiency. Gene Therapy. 11(12): 1001-1010 (2004).
  10. Huang SW, Wang J, Zhang PC, Mao HQ, Zhuo RX, Leong KW. Water-soluble and nonionic polyphosphoester: synthesis, degradation, biocompatibility and enhancement of gene expression in mouse muscle. Biomacromolecules. 5(2): 306-311 (2004).
  11. Li Y, Wang J, Lee CG, Wang CY, Gao SJ, Tang GP, Ma YX, Yu H, Mao HQ, Leong KW, Wang S. CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes. Gene Therapy. 11(1): 109-114 (2004).
  12. Wen J, Mao HQ, Li W, Lin KY, Leong KW. Biodegradable polyphosphoester micelles for gene delivery. Journal of Pharmaceutical Sciences. 93(8): 2142-2157 (2004).
  13. Wang J, Lee IL, Lim WS, Chia SM, Yu H, Leong KW, Mao HQ. Evaluation of collagen and methylated collagen as gene carriers. International Journal of Pharmaceutics. 279(1-2): 115-126 (2004).
  14. Wang J, Huang SW, Zhang PC, Mao HQ, Leong KW. Effect of side-chain structures on gene transfer efficiency of biodegradable cationic polyphosphoesters. International Journal of Pharmaceuticals. 265(1-2): 75-84 (2003).
  15. Wang J, Zhang PC, Lu HF, Ma N, Wang S, Mao HQ, Leong KW. New polyphosphoramidate with spermidine side chain mediates efficient gene transfer. Journal of Controlled Release. 83(1): 157-168 (2002).
  16. Wang J, Zhang PC, Mao HQ, Leong KW. Enhanced gene expression in mouse muscle by sustained release of plasmid DNA using PPE-EA as a carrier. Gene Therapy. 9(18): 1254-1261 (2002).
  17. Wang J, Mao HQ, Leong KW. A novel biodegradable gene carrier based on polyphosphoester. Journal of the American Chemical Society. 123(38): 9480-9481 (2001).
  18. Mao HQ, Roy K, Truong-Le VL, Janes K, Lin KY, Wang Y, August JT, Leong KW. Chitosan-DNA nanoparticles as gene delivery vehicles. Journal of Controlled Release. 70(3): 399-421 (2001).
  19. Truong-Le VL, Walsh SM, Schweibert E, Mao HQ, Guggino WB, August JT, Leong KW. Gene transfer by DNA-gelatin nanosphere. Archives of Biochemistry and Biophysics. 361(1): 47-56 (1999).
  20. Leong KW, Mao HQ, Truong-Le VL, Roy K, Walsh SM, August JT. DNA nanospheres as non-viral gene delivery vehicles. Journal of Controlled Release. 53(1): 183-193 (1998).

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Drug delivery  |  Growth factors  |  Nanofibers  |  Microspheres  |  Liposomes

  1. Alyssa G. Ashbaugh AG, Jiang X, Zheng J, Tsai AS, Kim WS, Thompson JM, Miller RJ, Shahbazian JH, Wang Y, Ordonez AA, Chang YS, Jain SK, Jones LC, Sterling RS, Mao HQ*, Miller LS*. Polymeric nanofiber coating with tunable combinatorial antibiotic delivery prevents biofilm-associated infection in vivo. Proceedings of National Academy of Sciences, U. S. A. In press (2016).
  2. Kashiwabuchi F, Parikh K, Omiadze R, Zhang S, Luo L, Patel H, Xu Q, Ensign L, Mao H-Q, Hanes J, McDonnell PJ. Development of absorbable, antibiotic-eluting sutures for ophthalmic surgery. Translational Vision Science & Technology. In press, (2016).
  3. Hickey JW, Santos JL, Williford JM, Mao HQ. Control of polymeric nanoparticle size to improve therapeutic delivery. J Control Release. 219: 536-47 (2015). doi: 10.1016/j.jconrel.2015.10.006. PMID: 26450667.
  4. Yu YQ, Jiang XQ, Gao S, Ma R, Jin Y, Jin X, Peng SY, Mao HQ, Li JT. Local delivery of VEGF via nanofiber matrix improves liver regeneration after extensive hepatectomy in rats. Journal of Biomedical Nanotechnology. 10(11): 3407-3415 (2014).
  5. Fang N, Wang J, Mao HQ, Leong KW, Chan V. BHEM-Chol/DOPE liposome induced perturbation of phospholipid bilayer. Colloids and Surfaces B: Biointerfaces. 29(4): 233-245 (2003).
  6. Zhao Z, Wang J, Mao HQ, Leong KW. Polyphosphoesters in drug and gene delivery. Advanced Drug Delivery Reviews. 55(4): 483-499 (2003).
  7. Xu XY, Yu H, Mao HQ, Gao S, Leong KW, Wang S. Polyphosphoester microspheres for sustained release of biologically active nerve growth factor. Biomaterials. 23(17): 3765-3772 (2002).

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Biomaterials for Regenerative Engineering

Stem Cells  |  Nanofibers  |  Hydrogel  |  Composite  |  Expansion  |  Differentiation

  1. Sluch VM, Davis CH, Ranganathan V, Kerr JM, Krick K, Martin R, Berlinicke CA, Marsh-Armstrong N, Diamond JS, Mao HQ, Zack DJ*. Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Sci Rep. 5: 16595 (2015). doi: 10.1038/srep16595. PMID: 26563826.
  2. Joseph M, Das M, Kanji S, Lu J, Aggarwal R, Chakroborty D, Sarkar C, Yu H, Mao HQ, Basu S, Pompili VJ, Das H. Retention of stemness and vasculogenic potential of human umbilical cord blood stem cells after repeated expansions on PES-nanofiber matrices. Biomaterials. 35(30): 8566-8575 (2014). PMID: 25002260.
  3. Ren YJ, Zhang S, Mi R, Liu Q, Zeng X, Rao M, Hoke A, Mao HQ. Enhanced differentiation of human neural crest stem cells towards the Schwann cell lineage by aligned electrospun fiber matrix. Acta Biomaterialia. 9 (8): 7727-7736 (2013). PMID: 23628775.
  4. Lu J, Kanji S, Aggarwal R, Das M, Joseph M, Wu LC, Mao HQ, Pompili VJ, Hadjiconstantinou M, Das H. Umbilical cord blood-derived hematopoietic stem cells improve dopaminergic neuron morphology in the MPTP-mice. Frontier in Biosciences. 18 (3): 970-981 (2013). PMID: 23747860.
  5. Aggarwal R, Lu J, Kanji S, Joseph M, Das M, Noble GJ, McMichael BK, Agarwal S, Hart RT, Sun Z, Lee BS, Rosol TJ, Jackson R, Mao HQ, Pompili VJ, Das H. Human umbilical cord blood-derived CD34+ cells reverse osteoporosis in NOD/SCID mice by altering osteoblastic and osteoclastic activities. PLoS ONE. 7(6): e39365 (2012). PMID: 22724005.
  6. Jiang X, Christopherson GT, Mao HQ. The effect of nanofiber surface amine density and conjugate structure on the adhesion and proliferation of human hematopoietic progenitor cells. Interface Focus. 1(10): 725-733 (2011).
  7. Mahairaki V, Lim SH, Christopherson GT, Xu L, Nasonkin I, Yu C, Mao HQ, Koliatsos VE. Nanofiber Matrices Promote the Neuronal Differentiation of Human Embryonic Stem Cell-Derived Neural Precursors In Vitro. Tissue Engineering, Part A. 17(5-6): 855-863 (2011). PMID: 20973749.
  8. Lim SH, Liu XY, Song H, Yarema KJ, Mao HQ. The effect of nanofiber-guided cell alignment on the preferential differentiation of neural stem cells. Biomaterials. 31(34): 9031-9039 (2010).
  9. Mao HQ, Lim SH, Zhang S, Christopherson GT, Kam K, Fischer S., “Nanofiber matrix as artificial stem cell niche”, In Biomaterials As Stem Cell Niche as part of a Series: “Studies in Mechanobiology, Tissue Engineering and Biomaterials”, Editor(s): K. Roy and A. Gefen. Springer-Verlag, New York, NY (2010). [Book Chapter]
  10. Das H, George JC, Joseph M, Das M, Abdulhameed N, Blitz A, Khan M, Sakthivel R, Mao HQ, Hoit BD, Kuppusamy P, Pompili VJ. Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model. PLoS One. 4(10): e7325 (2009). PMID: 19809493.
  11. Lim SH, Mao HQ. Electrospun scaffolds for stem cell engineering. Advanced Drug Delivery Reviews. 61(12): 1084-1096 (2009). PMID: 19647024.
  12. Das H, Abdulhameed N, Joseph M, Sakthivel R, Mao HQ, Pompili VJ. Ex vivo nanofiber expansion and genetic modification of human cord blood-derived progenitor/stem cells enhances vasculogenesis. Cell Transplantation. 18(3): 305-318 (2009). PMID: 19558779.
  13. Christopherson GT, Song HJ, Mao HQ. The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation. 30(4): 556-564 (2009).
  14. Chua KN, Chai C, Lee PC, Ramakrishna S, Leong KW, Mao HQ. Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor cells. Experimental Hematology. 35: 771–781 (2007).
  15. Chua KN, Chai C, Lee PC, Tang YN, Ramakrishna S, Leong KW, Mao HQ. Surface-Aminated Electrospun Nanofibers Enhance Adhesion and Expansion of Human Umbilical Cord Blood Hematopoietic Stem/Progenitor Cells. Biomaterials. 27(36): 6043-6051 (2006).
  16. Jiang XS, Chai C, Zhang Y, Zhuo RX, Mao HQ, Leong KW. Surface-immobilization of adhesion peptides on substrate for ex vivo expansion of cryopreserved umbilical cord blood CD34+ Biomaterials. 27(13): 2723-2732 (2006).
  17. Feng Q, Chai C, Jiang XS, Leong KW, Mao HQ. Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin. Journal of Biomedical Materials Research, Part A. 78(4): 781-791 (2006).

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Neural regeneration  |  Nanofibers  |  Tissue engineering  |  Transcription modification

  1. Roman JA, Reucroft I, Martin RA, Hurtado A, Mao HQ. Local release of paclitaxel from aligned, electrospun microfibers promotes axonal extension. Advanced Healthcare Materials. doi: 10.1002/adhm.201600415, in press. (2016). PMID: 27581383.
  2. Li X, Kozielski K, Cheng YH, Liu H, Zamboni CG, Green J, Mao HQ. Nanoparticle-mediated conversion of primary human astrocytes into neurons and oligodendrocytes. Biomaterials Science. 4(7): 1100-1112 (2016). doi: 10.1039/c6bm00140h; PMID: 27328202.
  3. Li X, Tzeng SY, Liu X, Tammia M, Cheng YH, Rolfe A, Sun D, Zhang N, Green JJ, Wen X*, Mao HQ*. Nanoparticle-mediated transcriptional modification enhances neuronal differentiation of human neural stem cells following transplantation in rat brain. Biomaterials. 84: 157-166 (2016). doi: 10.1016/j.biomaterials.2016.01.037. PMID: 26828681.
  4. Khalifian S, Sarhane KA, Tammia M, Ibrahim Z, Mao HQ, Cooney DS, Shores JT, Lee WP, Brandacher G. Stem cell-based approaches to improve nerve regeneration: potential implications for reconstructive transplantation? Archivum Immunologiae et Therapiae Experimentalis. 63(1): 15-30 (2015).
  5. Krick K, Tammia M, Martin R, Höke A, Mao HQ. Signaling cue presentation and cell delivery to promote nerve regeneration. Current Opinions in Biotechnology. 22(5): 741-746 (2011). PMID: 21531127.
  6. Jiang X, Lim SH, Mao HQ, Chew SY. Current applications and future perspectives of artificial nerve conduits. Experimental Neurology. 223(1): 86-101 (2010).
  7. Xu X, Yee WC, Hwang PYK, Yu H, Wan ACA, Gao S, Boon KL, Mao HQ, Leong KW, Wang S. Peripheral nerve regeneration with sustained release of poly(phosphoester) microencapsulated nerve growth factor within nerve guide conduits. Biomaterials. 24(13): 2405-2412 (2003).
  8. Wang S, Wan ACA, Xu XY, Gao SJ, Mao HQ, Leong KW, Yu H. A new nerve guide conduit material composed of a biodegradable poly(phosphoester). Biomaterials. 22(10): 1157-69 (2001).
  9. Wan ACA, Mao HQ, Wang S, Leong KW, Ong L, Yu H. Fabrication of poly(phosphoester) nerve guides by immersion precipitation and the control of porosity. Biomaterials. 22(10): 1147-56 (2001).

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Soft tissue regeneration  |  Nanofibers  |  Hydrogel  |  Composite  |  Skeletal tissue regeneration  |  Vascular engineering

  1. Cook CA, Huri PY, Ginn BP, Gilbert-Honick J, Somers SM, Temple JP, Mao HQ, Grayson WL. Characterization of a novel bioreactor system for 3D cellular mechanobiology studies. Biotechnol Bioeng. (2016). doi: 10.1002/bit.25946. PMID: 26825810.
  2. Barreto-Ortiz SF, Fradkin J, Eoh J, Trivero J, Davenport M, Ginn B, Mao HQ, Gerecht S. Fabrication of 3-dimensional multicellular microvascular structures. FASEB J. 29(8): 3302-14 (2015). doi: 10.1096/fj.14-263343. PMID: 25900808.
  3. Yalanis GC, Reddy S, Martin R, Choi J, Brandacher G, Mao HQ*, Sacks JM*. An Injectable Nanofiber-Hydrogel Composite with Interfacial Bonding for Soft Tissue Filling and Regeneration. Plast Reconstr Surg. 136(4 Suppl): 153-4 (2015). doi: 10.1097/01.prs.0000472477.01873.45. PMID: 26397687.
  4. Barreto-Ortiz SF, Zhang S, Davenport M, Fradkin J, Ginn BP, Mao HQ, Gerecht S. A novel in vitro model for microvasculature reveals regulation of circumferential ECM organization by curvature. PLoS One. 8(11): e81061 (2013). doi: 10.1371/journal.pone.0081061. PMID: 24278378.

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Cell-Biomaterials Interface  |  Liver tissue engineering

  1. Gibson M, Beachley V, Coburn J, Bandinelli PA, Mao HQ, Elisseeff J. Tissue extracellular matrix nanoparticle presentation in electrospun nanofibers. Biomedical Research International. 2014: 469120 (2014). doi: 10.1155/2014/469120. PMID: 24971329.
  2. Coburn J, Gibson M, Bandalini PA, Laird C, Mao HQ, Moroni L, Seliktar D, Elisseeff J. Biomimetics of the Extracellular Matrix: An Integrated Three-Dimensional Fiber-Hydrogel Composite for Cartilage Tissue Engineering. Smart Structures and Systems. 7(3): 213-222 (2011). PMID: 22287978.
  3. Fischer SE, Mi L, Mao HQ, Harden JL. Biofunctional coatings via targeted covalent cross-linking of associating triblock proteins. Biomacromolecules. 10(9): 2408-2417 (2009). PMID: 19655714.
  4. Fischer SE, Liu X, Mao HQ, Harden JL, Controlling cell adhesion to surfaces via associating bioactive triblock proteins. 28: 3325–3337 (2007).
  5. Chua KN, Tang YN, Quek CH, Ramakrishna S, Leong KW, Mao HQ. Dual-functional fibrous scaffold enhances P450 activity of cultured primary rat hepatocytes. Acta Biomaterialia. 3: 643–650 (2007).
  6. Hoque ME, Mao HQ, Ramakrishna S. Hybrid braided 3-D scaffold for bioartificial liver assist devices. Journal of Biomaterials Science-Polymer Edition. 18(1): 45-58 (2007).
  7. Lu HF, Lim WS, Zhang PC, Chia SM, Yu H, Mao HQ, Leong KW. Galactosylated PVDF hollow fiber bioreactor for hepatocyte culture, Tissue Engineering. 11(11-12):1667-77 (2005).
  8. Chua KN, Lim WS, Zhang P, Lu H, Wen J, Ramakrishna S, Leong KW, Mao HQ. Stable immobilization of rat hepatocyte spheroids on galactosylated nanofiber scaffold. Biomaterials. 26(15): 2537-2547 (2005).
  9. Tan WJ, Teo GP, Liao K, Leong KW, Mao HQ, Chan V. Adhesion contact dynamics of primary hepatocytes on poly(ethylene terephthalate) surface. Biomaterials. 26(8): 891-898 (2005).
  10. Ng S, Wu YN, Zhou Y, Toh YE, Ho ZZ, Chia SM, Zhu JH, Mao HQ, Yu H. Optimization of 3-D hepatocyte culture by controlling the physical and chemical properties of the extra-cellular matrices. Biomaterials. 26(16): 3153-3163 (2005).
  11. Chia SM, Lin P, Quek CH, Yin C, Mao HQ, Leong KW, Xu X, Goh CH, Ng M, Yu H. Engineering microenvironment for expansion of sensitive anchorage-dependent mammalian cells. Journal of Biotechnology. 118(4): 434-447 (2005).
  12. Lu HF, Chua KN, Zhang PC, Lim WS, Ramakrishna S, Leong KW, Mao HQ. Three-dimensional co-culture of rat hepatocyte spheroids and NIH/3T3 fibroblasts enhances hepatocyte functional maintenance. Acta Biomaterialia. 1(5): 399-410 (2005).
  13. Quek CH, Li J, Sun T, Chan ML, Mao HQ, Gan LM, Leong KW, Yu H. Photo-crosslinkable microcapsules formed by polyelectrolyte copolymer and modified collagen for rat hepatocyte encapsulation. Biomaterials. 25(17): 3531-40 (2004).
  14. Wan AC, Mao HQ, Wang S, Phua SH, Lee GP, Pan J, Lu S, Wang J, Leong KW. Poly(phosphoester) ionomers as tissue-engineering scaffolds. Journal of Biomedical Materials Research. 70B(1): 91-102 (2004).
  15. Mao HQ and Leong KW, “Polymeric scaffolds for tissue engineering,” in Frontiers in Biomedical Engineering, Eds. Huang N and Woo S, Kluwer Academic / Plenum Publishers, New York, NY (2004). [Book Chapter]
  16. Ying L, Yin C, Zhuo RX, Leong KW, Mao HQ, Kang ET, Neoh KG. Immobilization of galactose ligands on acrylic acid graft-copolymerized poly(ethylene terephthalate) film and its application to hepatocyte culture. Biomacromolecules. 4(1): 157-165 (2003).
  17. Yin C, Liao K, Mao HQ, Leong KW, Zhuo RX, Chan V. Adhesion contact dynamics of HepG2 cells on galactose immobilized substrates. Biomaterials. 24(5): 837-850 (2003).
  18. Yin C, Chia SM, Quek CH, Yu H, Zhuo RX, Leong KW, Mao HQ. Microcapsules with improved mechanical stability for hepatocyte culture. Biomaterials. 24(10): 1771-1780 (2003).
  19. Lu HF, Lim WS, Zhang PC, Wang J, Tang ZQ, Chia SM, Yu H, Leong KW, Mao HQ. Galactosylated PVDF membrane promotes hepatocyte attachment and functional maintenance. Biomaterials. 24(27): 4893-4903 (2003).
  20. Yin C, Ying L, Zhang PC, Zhuo RX, Kang ET, Leong KW, Mao HQ. High density of immobilized galactose ligand enhances hepatocyte attachment and function. Journal of Biomedical Materials Research. 67A(4): 1093-1104 (2003).
  21. Chia SM, Wan ACA, Quek CH, Mao HQ, Xu X, Shen L, Ng ML, Leong KW, Yu H. Multi-layer live cell microcapsules for tissue engineering. Biomaterials. 23(3): 849-856 (2002).

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Biomaterials for Immunoengineering

  1. Dinglasan RR, Armistead JS, Nyland FJ, Mao HQ. Single-dose microparticle delivery of a malaria transmission-blocking vaccine elicits a long-lasting functional antibody response. Current Molecular Medicine. 13(4): 479-487 (2013). PMID: 23331003.
  2. Tang ZH, Liang S, Potter J, Jiang X, Mao HQ, Li Z. Tim-3/galectin-9 regulate the homeostasis of hepatic NKT cells in a murine model of nonalcoholic fatty liver disease. Journal of Immunology. 190(4): 1788-1796 (2013). PMID: 23296703.
  3. Chew JL, Wolfowicz CB, Mao HQ, Leong KW, Chua KY. Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. Vaccine. 21(21-22): 2720-2729 (2003).
  4. Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan-DNA nanoparticles generates immunological protection in a murine model of peanut allergy. Nature Medicine. 5(4): 387-391 (1999).
  5. Zhuo RX, Wang J, Mao HQ, Zang C, Ye Y. Immunomodulation of synthesized polymers containing phosphorus in the backbone-Effect on the proliferation of lymphocytes. Chinese Journal of Reactive Polymers. 6(1): 67-76 (1997).
  6. Mao HQ, Zhuo RX, Fan CL. Synthesis and biological properties of polymer immunoadjuvants. Polymer Journal. 25(5): 499-506 (1993).

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Biomaterials Synthesis and Processing

  1. Zhang S, Liu X, Barreto-Ortiz SF, Yu Y, Ginn BP, DeSantis NA, Hutton DL, Grayson WL, Cui FZ, Korgel BA, Gerecht S, Mao HQ. Creating polymer hydrogel microfibres with internal alignment via electrical and mechanical stretching. Biomaterials. 35(10): 3243-3251 (2014). PMID: 24439410.
  2. Wall BD, Diegelmann SR, Zhang S, Dawidczyk TJ, Wilson WL, Katz HE, Mao HQ, Tovar JD. Aligned macroscopic domains of optoelectronic nanostructures prepared via shear-flow assembly of peptide hydrogels. Advanced Materials. 23(43): 5009-5014 (2011), PMID: 22180891 (Cover Article).
  3. Lin K, Chua KN, Christopherson GT, Lim S and Mao HQ. Reducing electrospun nanofiber diameter and variability using cationic amphiphiles. Polymer. 48: 6384-6394 (2007).
  4. Chu LQ, Mao HQ, Knoll W. In situ characterization of moisture sorption/desorption in thin polymer films using optical waveguide spectroscopy. Polymer. 47(21): 7406-7413 (2006).
  5. Chu LQ, Tan WJ, Mao HQ, Knoll W. Characterization of UV-induced graft polymerization of poly(acrylic acid) using optical waveguide spectroscopy. Macromolecules. 39(25): 8742-8746 (2006).
  6. Fang N, Tan WJ, Leong KW, Mao HQ, Chan V. pH-responsive adhesion of phospholipid vesicle on poly(acrylic acid) cushion grafted to poly(ethylene terephthalate) surface. Colloids Surf B Biointerfaces. 42(3-4): 245-252 (2005).
  7. Mao HQ, Shipanova I, Zhao Z, Dang W, Brown A, Leong KW. Biodegradable poly(terephthalate-co-phosphate)s: Synthesis, characterization and drug release properties. Journal of Biomaterials Science-Polymer Edition. 16(2): 135-161 (2005).
  8. Hu JJ, Yin C, Mao HQ, Tamada K, Knoll WG. Functionalization of poly(ethylene terephthalate) film by pulsed plasma deposition of maleic anhydride. Advanced Functional Materials. 13(9): 692-697 (2003).
  9. Fang N, Chan V, Wan KT, Mao HQ, Leong KW. Colloidal adhesion of phospholipid vesicles: high-resolution reflection interference contrast microscopy and theory. Colloids and Surfaces B: Biointerfaces. 25(4): 347-362 (2002).
  10. Fang N, Chan V, Mao HQ, Leong KW. Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH. Biomacromolecules. 2(4): 1161-1168 (2001).
  11. Chan V, Mao HQ, Leong KW. Chitosan-induced perturbation of dipalmitoyl-sn-glycero-3-phosphocholine membrane bilayer. Langmuir. 17(12): 3749-3756 (2001).
  12. Mao HQ, Zhao Z, Dang W, Shipanova-Kadiyala I, Leong KW. “Biodegradable poly(phosphoester)s”, in Encyclopedia of Controlled Drug Delivery. pp. 45-60. First Edition, Ed. E. Mathiowitz, Johns Wiley & Sons, Inc. New York, NY (1999). [Book Chapter]
  13. Zhuo RX, Wang J, Mao HQ. Syntheses of poly(phosphate-urethane)s as drug release materials. Chemical Journal of Chinese Universities. 18 (7): 1207-1211 (1997).
  14. Leong KW, Mao HQ, Zhuo RX, Biodegradable polymers with a phosphoryl-containing backbone: tissue engineering and controlled drug delivery applications. Chinese Journal of Polymer Science. 13(4): 289-314 (1995).
  15. Mao HQ, Zhuo RX, Fan CL, Jiang XS, Liu WP, Yi H, Studies on the phosphorylating polycondensation catalyzed by 4-dimethylaminopyridine, Macromolecular Chemistry and Physics. 196: 655-658 (1995).
  16. Mao HQ, Zhuo RX, Fan CL, Fan LH, Fu YP. Synthesis of new polyphosphates as drug release materials. Chemical Journal of Chinese Universities. 14(12): 1743-1747 (1993).

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Patents

Issued

US PAT. NO.     Title

  1. 9,539,334  Orally dissolving thin films containing allergens and methods of making and use
  2. 9,539,009  Biological Tissue Connection and Repair Devices and Methods of Using Same
  3. 9,533,068  Drug Loaded Microfiber Sutures for Ophthalmic Application
  4. 8,669,106  Erythrocytes differentiated in vitro from nanofiber expanded CD133+ cells
  5. 8,361,502  Compositions and methods for the expansion and differentiation of stem cells
  6. 7,417,110  Biodegradable polyphosphoramidates for controlled release of bioactive substances
  7. 7,345,138  Biodegradable polyphosphates for controlled release of bioactive substances
  8. 6,899,731  Controlled delivery of therapeutic agents by insertable medical devices
  9. 6,852,709  Biologically useful polyphosphates
  10. 6,805,876  Phosphate based biodegradable polymers
  11. 6,800,672  Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
  12. 6,600,010  Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same
  13. 6,548,302  Polymers for delivery of nucleic acids
  14. 6,485,737  Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles and methods of using the same
  15. 6,419,709  Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
  16. 6,403,675  Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
  17. 6,376,644  Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
  18. 6,322,797  Biodegradable terephthalate polyester-poly (phosphate) polymers, compositions, articles, and methods for making and using the same
  19. 6,238,687  Biodegradable polymers, compositions, articles and methods for making and using the same
  20. 6,166,173  Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same
  21. 6,153,212  Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
  22. 6,008,318  Two-stage solution polymerization of high molecular weight poly(phosphoesters)
  23. 5,972,707  Gene delivery system
  24. 5,912,225  Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same

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Other Patents:

  1. Lu Z, Zhao X, Mao HQ, Zhuo RX, New magnetic resonance imaging contrast agents. P.R.C. Patent CN941115666 (1994).

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Published Patent Applications:

  1. O’Brien-Coon D, Sinha A, Manabe Y, Lamicchane G, Neira H, Mao HQ, Mistry H, Chopra A, Jiang X, Cationic polymer systems for selective bacterial capture. U.S. Patent Appl. No. WO2015171786 A1; PCT/US2015/029498 (Filed May 6, 2015, Published Nov 12, 2015).
  2. Mao HQ, Zhang S, Liu X, Ginn BP, Electro-mechanically stretched micro fibers and methods of use thereof. U.S. Patent Appl. No. 20150118195 A1 (Filed Apr 30, 2013, Published Apr 30, 2015).
  3. Gerecht S, Barreto OSF, Zhang S, Mao HQ. Elecrostretched polymer microfibers for microvasculature development. U.S. Patent Appl. No. WO 2015066526 A1, US20150118747 (Filed October 31, 2014, Published May 7, 2015).
  4. Wang TH, Beh, C, Kraitchman DL. Mao HQ, Systems and methods for high-throughput microfluidic bead production. US 9156189 B2, PCT/US2011/054598, WO2012047802A2 (July 18, 2013), US20130183246 A1, PCT/US2011/054598 (July 18, 2013). Published Oct. 13, 2015.
  5. Hoke A, Lim SH, Liu X, Mao HQ. Biodegradable Nerve Guides. U.S. Patent Appl. No. 14/081381; 20140081297 A1 (Filed November 15, 2013, Published March 20, 2014).
  6. Mao HQ, Zhang S, Liu X, Ginn BP. Electro-mechanically stretched micro fibers and methods of use thereof. WO2013165975 A1, PCT/US2013/038805 (April 30, 2013); US Patent Application. 61/665,498 (April 30, 2012).
  7. Nakanishi M, Patil R, Mao HQ. Stabilized polyribonucleotide nanoparticles WO 2012094574 A3. PCT/US2012/020445 (January 6, 2012).
  8. Mao HQ, Yin C, Zhuo RX, Leong KW. Method of immobilization of clusters of ligands on polymer surface and use in cell engineering. U.S. Patent Application 2005/0058685 A1 (March 17, 2005), WO2004027050 B1 (May 13, 2004).
  9. Mao HQ, Yu CK, Truong VL, Li Y, Rangaraj D, Jiang XS, Shah SR, Sing D., Quick-dissolving oral thin film for targeted delivery of therapeutic agents, U.S. Patent 2011/0305768 A1, Application number 13/002222 (December 15, 2011).

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